Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging
from yeast to humans. They regulate diverse biological processes both during development …

Virus-like nanoparticles (VLPs) are natural polymer-based nanomaterials that mimic viral
structures through the hierarchical assembly of viral coat proteins, while lacking viral …

With the ability to fully sequence tumor genomes/exomes, the quest for cancer driver genes
can now be undertaken in an unbiased manner. However, obtaining a complete catalog of …

Prostate cancer is the second most commonly diagnosed malignancy among men
worldwide. Recurrently mutated in primary and metastatic prostate tumors, FOXA1 encodes …

Abstract FoxA1 (FOXA1) is a pioneering transcription factor of the androgen receptor (AR)
that is indispensible for the lineage-specific gene expression of the prostate. To date, there …

While highly promising in medicine, gene therapy requires delivery agents to protect and
target nucleic acid therapeutics. We developed a plant viral siRNA delivery platform making …

The remarkable variation in prostate cancer clinical behavior represents an opportunity to
identify and understand molecular features that can be used to stratify patients into clinical …

GATA-3, a member of the GATA family of zinc-finger DNA binding proteins, and FOXA1, a
member of the forkhead transcription factor family, are both associated with estrogen …

L-type amino acid transporter 1 (LAT1) plays a role in transporting essential amino acids
including leucine, which regulates the mTOR signaling pathway. Here, we studied the …

Purpose: Cancer cells require massive amounts of amino acids for survival. LAT1 (L-type
amino acid transporter 1) transports essential amino acids, including leucine, which trigger …