Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …

Microtubules are non-covalent mesoscale polymers central to the eukaryotic cytoskeleton.
Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin …

Microtubules are essential dynamic polymers composed of α/β-tubulin heterodimers. They
support intracellular trafficking, cell division, cellular motility, and other essential cellular …

BACKGROUND Neurons are polarized cells with extreme geometries. Multiple dendrites
and one axon generally emerge from a single cell body and establish synaptic contacts with …

Understanding the basis for cellular growth, proliferation, and function requires determining
the roles of essential genes in diverse cellular processes, including visualizing their …

The detyrosination-tyrosination cycle involves the removal and religation of the C-terminal
tyrosine of α-tubulin and is implicated in cognitive, cardiac, and mitotic defects. The …

Review covering up to 07/2019 (−)-Parthenolide is a germacrane sesquiterpene lactone,
available in ample amounts from the traditional medical plant feverfew (Tanacetum …

Post-translational modifications (PTM) involve enzyme-mediated covalent addition of
functional groups to proteins during or after synthesis. These modifications greatly increase …

Background Brain metastasis (BM) is one of the principal causes of mortality for lung cancer
patients. While the molecular events that govern BM of lung cancer remain frustrating …

Background: Hypertrophic cardiomyopathy (HCM) is the most common genetic heart
disease. While≈ 50% of patients with HCM carry a sarcomere gene mutation (sarcomere …