Distilling biologically meaningful information from cancer genome sequencing data requires
comprehensive identification of somatic alterations using rigorous computational methods …

Structural variations (SVs) including gene presence/absence variations and copy number
variations are a common feature of genomes in plants and, together with single nucleotide …

Defining the transition from benign to malignant tissue is fundamental to improving early
diagnosis of cancer. Here we use a systematic approach to study spatial genome integrity in …

Most known pathogenic point mutations in humans are C• G to T• A substitutions, which can
be directly repaired by adenine base editors (ABEs). In this study, we investigated the …

Zero hunger and good health could be realized by 2030 through effective conservation,
characterization and utilization of germplasm resources. So far, few chickpea (Cicer …

The Hi-C technique has been shown to be a promising method to detect structural variations
(SVs) in human genomes. However, algorithms that can use Hi-C data for a full-range SV …

Advancements in precision oncology over the past decades have led to new therapeutic
interventions, but the efficacy of such treatments is generally limited by an adaptive process …

Ovarian cancer (OC) is a heterogeneous disease usually diagnosed at a late stage.
Experimental in vitro models that faithfully capture the hallmarks and tumor heterogeneity of …

Breast cancer (BC) comprises multiple distinct subtypes that differ genetically,
pathologically, and clinically. Here, we describe a robust protocol for long-term culturing of …

Accumulating evidence indicates that patient-derived organoids (PDOs) can predict drug
responses in the clinic, but the ability of PDOs to predict responses to chemoradiation in …