Toxicity of polyamines and their metabolic products

AE Pegg - Chemical research in toxicology, 2013 - ACS Publications
Polyamines are ubiquitous and essential components of mammalian cells. They have
multiple functions including critical roles in nucleic acid and protein synthesis, gene …

Targeting polyamine metabolism for cancer therapy and prevention

TR Murray-Stewart, PM Woster… - Biochemical …, 2016 - portlandpress.com
The chemically simple, biologically complex eukaryotic polyamines, spermidine and
spermine, are positively charged alkylamines involved in many crucial cellular processes …

[HTML][HTML] Polyamine oxidases play various roles in plant development and abiotic stress tolerance

Z Yu, D Jia, T Liu - Plants, 2019 - mdpi.com
Polyamines not only play roles in plant growth and development, but also adapt to
environmental stresses. Polyamines can be oxidized by copper-containing diamine …

[HTML][HTML] The involvement of polyamines catabolism in the crosstalk between neurons and astrocytes in neurodegeneration

M Cervelli, M Averna, L Vergani, M Pedrazzi, S Amato… - Biomedicines, 2022 - mdpi.com
In mammalian cells, the content of polyamines is tightly regulated. Polyamines, including
spermine, spermidine and putrescine, are involved in many cellular processes. Spermine …

Transcriptomics and metabolomics reveal Ca2+ overload and osmotic imbalance-induced neurotoxicity in earthworms (Eisenia fetida) under tri-n-butyl phosphate …

X Jiang, Y Yang, P Liu, M Li - Science of the Total Environment, 2020 - Elsevier
Tri-n-butyl phosphate (TNBP) is mass-produced and widely utilized in many products, which
has increasingly drawn concern about its potential environmental risks. However, little is …

Polyamines metabolism and breast cancer: state of the art and perspectives

M Cervelli, S Pietropaoli, F Signore… - Breast cancer research …, 2014 - Springer
Breast cancer (BC) is a common disease that generally occurs in women over the age of 50,
and the risk is especially high for women over 60 years of age. One of the major BC …

Pharmacological potential of biogenic amine–polyamine interactions beyond neurotransmission

F Sánchez‐Jiménez, MV Ruiz‐Pérez… - British Journal of …, 2013 - Wiley Online Library
Histamine, serotonin and dopamine are biogenic amines involved in intercellular
communication with multiple effects on human pathophysiology. They are products of two …

Supplementation with spermine during in vitro maturation of porcine oocytes improves early embryonic development after parthenogenetic activation and somatic cell …

JX Jin, S Lee, C Khoirinaya, A Oh… - Journal of animal …, 2016 - academic.oup.com
Spermine plays an important role in protection from reactive oxygen species (ROS) in
bacteria, yeast, and mammalian cells, but there are few studies on the effects of spermine on …

[HTML][HTML] Transgenic mouse overexpressing Spermine oxidase in Cerebrocortical neurons: astrocyte dysfunction and susceptibility to epileptic seizures

M Marcoli, C Cervetto, S Amato, C Fiorucci, G Maura… - Biomolecules, 2022 - mdpi.com
Polyamines are organic polycations ubiquitously present in living cells. Polyamines are
involved in many cellular processes, and their content in mammalian cells is tightly …

[HTML][HTML] Metabolomic Reprogramming of C57BL/6-Macrophages during Early Infection with L. amazonensis

M Mamani-Huanca, SM Muxel, SM Acuña… - International Journal of …, 2021 - mdpi.com
Leishmania survival inside macrophages depends on factors that lead to the immune
response evasion during the infection. In this context, the metabolic scenario of the host cell …