Cluster headache is a trigeminal autonomic cephalalgia characterised by extremely painful,
strictly unilateral, short-lasting headache attacks accompanied by ipsilateral autonomic …

Cold-inducible RNA-binding protein (CIRP) and RNA-binding motif protein 3 (RBM3) are
two evolutionarily conserved RNA-binding proteins that are transcriptionally upregulated in …

Objective To provide a summary of knowledge about the use of melatonin in the treatment of
primary headache disorders. Background Melatonin is secreted by the pineal gland; its …

Although clinically distinguishable, migraine and cluster headache share prominent features
such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine …

Background/Hypothesis Cluster headache displays uniquely rhythmic patterns in its attack
manifestation. This strong chronobiological influence suggests that part of the …

Cluster headache (CH) is a severe primary headache with a prevalence of 1/1000
individuals, and a predominance in men. Calcitonin gene-related peptide (CGRP) is a …

Circadian rhythms of physiology are the keys to health and fitness, as dysregulation, by
genetic mutations or environmental factors, increases disease risk and aggravates …

Objectives: We examine whether the lithium response is associated with changes in the
expression of core clock genes. Methods: The effect of a therapeutic concentration of lithium …

Background Despite advances in neuroimaging and electrophysiology, cluster headache's
pathogenesis remains unclear. This review will examine clinical neurophysiology studies …

Importance Genetic and environmental factors are thought to contribute to cluster headache,
and cluster headache can affect multiple members of a family. A thorough understanding of …