The utility of ETD mass spectrometry in proteomic analysis

LM Mikesh, B Ueberheide, A Chi, JJ Coon… - … et Biophysica Acta (BBA …, 2006 - Elsevier
Mass spectrometry has played an integral role in the identification of proteins and their post-
translational modifications (PTM). However, analysis of some PTMs, such as …

Methanobactin and the link between copper and bacterial methane oxidation

AA DiSpirito, JD Semrau, JC Murrell… - Microbiology and …, 2016 - Am Soc Microbiol
Methanobactins (mbs) are low-molecular-mass (< 1,200 Da) copper-binding peptides, or
chalkophores, produced by many methane-oxidizing bacteria (methanotrophs). These …

Common errors in mass spectrometry‐based analysis of post‐translational modifications

MS Kim, J Zhong, A Pandey - Proteomics, 2016 - Wiley Online Library
Mass spectrometry (MS) is a powerful tool to analyze complex mixtures of proteins in a high‐
throughput fashion. Proteome analysis has already become a routine task in biomedical …

Phosphoproteomic analysis of the developing mouse brain

BA Ballif, J Villen, SA Beausoleil, D Schwartz… - Molecular & Cellular …, 2004 - ASBMB
Proper development of the mammalian brain requires the precise integration of numerous
temporally and spatially regulated stimuli. Many of these signals transduce their cues via the …

Application of electron transfer dissociation (ETD) for the analysis of posttranslational modifications

J Wiesner, T Premsler, A Sickmann - Proteomics, 2008 - Wiley Online Library
Despite major advantages in the field of proteomics, the analysis of PTMs still poses a major
challenge; thus far, preventing insights into the role and regulation of protein networks …

Tyrosine sulfation as a protein post-translational modification

YS Yang, CC Wang, BH Chen, YH Hou, KS Hung… - Molecules, 2015 - mdpi.com
Integration of inorganic sulfate into biological molecules plays an important role in biological
systems and is directly involved in the instigation of diseases. Protein tyrosine sulfation …

Phosphoproteomics for the masses

PA Grimsrud, DL Swaney, CD Wenger… - ACS chemical …, 2010 - ACS Publications
Protein phosphorylation serves as a primary mechanism of signal transduction in the cells of
biological organisms. Technical advancements over the last several years in mass …

Structure Elucidation of the First Sex‐Inducing Pheromone of a Diatom

FA Klapper, C Kiel, P Bellstedt… - Angewandte Chemie …, 2023 - Wiley Online Library
Diatoms are abundant unicellular microalgae, responsible for≈ 20% of global
photosynthetic CO2 fixation. Nevertheless, we know little about fundamental aspects of their …

Chalkophores

GE Kenney, AC Rosenzweig - Annual review of biochemistry, 2018 - annualreviews.org
Copper-binding metallophores, or chalkophores, play a role in microbial copper
homeostasis that is analogous to that of siderophores in iron homeostasis. The best-studied …

Orthogonal Translation for Site-Specific Installation of Post-translational Modifications

Q Gan, C Fan - Chemical Reviews, 2024 - ACS Publications
Post-translational modifications (PTMs) endow proteins with new properties to respond to
environmental changes or growth needs. With the development of advanced proteomics …