[HTML][HTML] Weil's Disease—Immunopathogenesis, Multiple Organ Failure, and Potential Role of Gut Microbiota

P Petakh, V Isevych, A Kamyshnyi, V Oksenych - Biomolecules, 2022 - mdpi.com
Leptospirosis is an important zoonotic disease, causing about 60,000 deaths annually. In
this review, we have described in detail the immunopathogenesis of leptospirosis, the …

[HTML][HTML] Over-expression of miR-223 induces M2 macrophage through glycolysis alteration and attenuates LPS-induced sepsis mouse model, the cell-based therapy …

CP Dang, A Leelahavanichkul - PLoS One, 2020 - journals.plos.org
The attenuation of hyper-inflammation in sepsis with the administration of anti-inflammatory
macrophages is an interesting adjuvant therapy for sepsis. Because the induction of anti …

[HTML][HTML] Going micro in leptospirosis kidney disease

W Chancharoenthana, A Leelahavanichkul, MJ Schultz… - Cells, 2022 - mdpi.com
Leptospirosis is a zoonotic and waterborne disease worldwide. It is a neglected infectious
disease caused by Leptospira spp., as well as a reemerging disease and global public …

[HTML][HTML] Lactobacillus rhamnosus attenuates Thai chili extracts induced gut inflammation and dysbiosis despite capsaicin bactericidal effect against the probiotics, a …

W Panpetch, P Visitchanakun, W Saisorn… - PLoS …, 2021 - journals.plos.org
Because of a possible impact of capsaicin in the high concentrations on enterocyte injury
(cytotoxicity) and bactericidal activity on probiotics, Lactobacillus rhamnosus L34 (L34) and …

[HTML][HTML] LPS tolerance inhibits cellular respiration and induces global changes in the macrophage secretome

J Gillen, T Ondee, D Gurusamy, J Issara-Amphorn… - Biomolecules, 2021 - mdpi.com
Inflammatory response plays an essential role in the resolution of infections. However,
inflammation can be detrimental to an organism and cause irreparable damage. For …

[HTML][HTML] Design, synthesis and anti-inflammatory activity study of lansiumamide analogues for treatment of acute lung injury

L Song, G Li, W Guan, Z Zeng, Y Ou, T Zhao, J Li… - Biomedicine & …, 2023 - Elsevier
Acute lung injury (ALI) is an inflammation-mediated respiratory disease with a high mortality
rate. Medications with anti-inflammatory small molecules have been demonstrated in phase …

[HTML][HTML] Candida Administration Worsens Cecal Ligation and Puncture-Induced Sepsis in Obese Mice Through Gut Dysbiosis Enhanced Systemic Inflammation …

W Panpetch, V Sawaswong, P Chanchaem… - Frontiers in …, 2020 - frontiersin.org
Obesity induces gut leakage and elevates serum lipopolysaccharide (LPS), a major cell wall
component of Gram-negative bacteria, through gut translocation. Because Candida albicans …

[HTML][HTML] Obesity exacerbates lupus activity in Fc gamma receptor IIb deficient lupus mice partly through saturated fatty acid-induced gut barrier defect and systemic …

K Udompornpitak, A Charoensappakit… - Journal of innate …, 2023 - karger.com
The prevalence of obesity is increasing, and the coexistence of obesity and systemic lupus
erythematosus (lupus) is possible. A high-fat diet (HFD) was orally administered for 6 …

[HTML][HTML] BAM15, a mitochondrial uncoupling agent, attenuates inflammation in the LPS injection mouse model: an adjunctive anti-inflammation on macrophages and …

CP Dang, J Issara-Amphorn… - Journal of Innate …, 2021 - karger.com
Controlof immune responses through the immunometabolism interference is interesting for
sepsis treatment. Then, expression of immunometabolism-associated genes and BAM15, a …

Discovery of 4-oxo-N-phenyl-1, 4-dihydroquinoline-3-carboxamide derivatives as novel anti-inflammatory agents for the treatment of acute lung injury and sepsis

J Yang, M Wang, Y Xu, J Liao, X Li, Y Zhou… - European Journal of …, 2023 - Elsevier
Acute lung injury (ALI) and sepsis, characterized by systemic inflammatory response
syndrome, remain the major causes of death in severe patients. Inhibiting the release of …