The evolutionarily conserved p53 protein and its cellular pathways mediate tumour
suppression through an informed, regulated and integrated set of responses to …

Interest in the lysosome's potential role in anticancer therapies has recently been
appreciated in the field of immuno-oncology. Targeting lysosomes triggers apoptotic …

Photodynamic therapy (PDT) has emerged as a promising alternative to conventional
cancer therapies such as surgery, chemotherapy, and radiotherapy. PDT comprises the …

The endoplasmic reticulum (ER), comprises 60% of the total cell membrane and interacts
directly or indirectly with several cell organelles ie, Golgi bodies, mitochondria and …

Damage-associated molecular patterns (DAMPs) are endogenous danger molecules
produced in cellular damage or stress, and they can activate the innate immune system …

The endoplasmic reticulum (ER) is an organelle equipped with mechanisms for proper
protein folding, trafficking, and degradation to maintain protein homeostasis in the secretory …

Immunogenic cell death (ICD) is a type of death, which has the hallmarks of necroptosis and
apoptosis, and is best characterized in malignant diseases. Chemotherapeutics …

The endoplasmic reticulum (ER) has diverse functions, and especially misfolded protein
modification is in the focus of this review paper. With a highly regulatory mechanism, called …

The integrated stress response is characterized by the phosphorylation of eukaryotic
initiation factor-2α (eIF2α) on serine 51 by one out of four specific kinases (EIF2AK1 to 4) …

Endoplasmic reticulum (ER) is the main organelle for the synthesis, folding, and processing
of secretory and transmembrane proteins. Pathological stimuli including hypoxia, ischaemia …