Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy
S Marchiano, K Nakamura, H Reinecke, L Neidig… - Cell Stem Cell, 2023 - cell.com
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) offer a promising cell-
based therapy for myocardial infarction. However, the presence of transitory ventricular …
based therapy for myocardial infarction. However, the presence of transitory ventricular …
Maturation of human pluripotent stem cell derived cardiomyocytes in vitro and in vivo
MJ Gomez-Garcia, E Quesnel, R Al-Attar… - Seminars in cell & …, 2021 - Elsevier
Human pluripotent stem cell derived cardiomyocytes (hPSC-CMs) represent an
inexhaustible cell source for in vitro disease modeling, drug discovery and toxicity …
inexhaustible cell source for in vitro disease modeling, drug discovery and toxicity …
In vitro matured human pluripotent stem cell–derived cardiomyocytes form grafts with enhanced structure and function in injured hearts
W Dhahri, T Sadikov Valdman, D Wilkinson, E Pereira… - Circulation, 2022 - Am Heart Assoc
Background: Human pluripotent stem cell (hPSC)–derived cardiomyocytes (hPSC-CMs)
have tremendous promise for application in cardiac regeneration, but their translational …
have tremendous promise for application in cardiac regeneration, but their translational …
The effect of sex and age on ex vivo cardiac electrophysiology: insight from a guinea pig model
KT Haq, BL Cooper, F Berk… - American Journal of …, 2023 - journals.physiology.org
Highlighting the importance of sex as a biological variable, we recently reported sex
differences in guinea pig in vivo electrocardiogram (ECG) measurements. However …
differences in guinea pig in vivo electrocardiogram (ECG) measurements. However …
Carfilzomib treatment causes molecular and functional alterations of human induced pluripotent stem cell–derived cardiomyocytes
Background Anticancer therapies have significantly improved patient outcomes; however,
cardiac side effects from cancer therapies remain a significant challenge. Cardiotoxicity …
cardiac side effects from cancer therapies remain a significant challenge. Cardiotoxicity …
KairoSight: Open-source software for the analysis of cardiac optical data collected from multiple species
Cardiac optical mapping, also known as optocardiography, employs parameter-sensitive
fluorescence dye (s) to image cardiac tissue and resolve the electrical and calcium …
fluorescence dye (s) to image cardiac tissue and resolve the electrical and calcium …
Analysis of the effects of bench-scale cell culture platforms and inoculum cell concentrations on PSC aggregate formation and culture
DG Iworima, RK Baker, JM Piret… - Frontiers in Bioengineering …, 2023 - frontiersin.org
Introduction: Human pluripotent stem cells (hPSCs) provide many opportunities for
application in regenerative medicine due to their ability to differentiate into cells from all …
application in regenerative medicine due to their ability to differentiate into cells from all …
Graft–host coupling changes can lead to engraftment arrhythmia: a computational study
After myocardial infarction (MI), a significant portion of heart muscle is replaced with scar
tissue, progressively leading to heart failure. Human pluripotent stem cell‐derived …
tissue, progressively leading to heart failure. Human pluripotent stem cell‐derived …
Computational modeling of aberrant electrical activity following remuscularization with intramyocardially injected pluripotent stem cell-derived cardiomyocytes
KY Joseph, JA Liang, SH Weinberg… - Journal of molecular and …, 2022 - Elsevier
Acute engraftment arrhythmias (EAs) remain a serious complication of remuscularization
therapy. Preliminary evidence suggests that a focal source underlies these EAs stemming …
therapy. Preliminary evidence suggests that a focal source underlies these EAs stemming …
Surgical strategies in single ventricle management of neonates and infants
C Haller, DJ Barron - Canadian Journal of Cardiology, 2022 - Elsevier
No area of congenital heart disease has undergone greater change and innovation than
single ventricle management over the past 20 years. Surgical and catheterisation laboratory …
single ventricle management over the past 20 years. Surgical and catheterisation laboratory …