Metabolic reprogramming is a hallmark of cancer and allows tumour cells to meet the
increased energy demands required for rapid proliferation, invasion, and metastasis …

Diabetes mellitus is a chronic metabolic disease commonly associated with complications
such as cardiovascular disease, nephropathy and neuropathy, the incidence of which is …

Background Peptide proteolysis-targeting chimeras (p-PROTACs) with advantages of high
specificity and low toxicity have emerged as a powerful technology of targeted protein …

Cholangiocarcinoma (CCA) is a lethal cancer in that the incidence is now increasing
worldwide. N-acetylgalactosaminyltransferase 5 (GALNT5), an enzyme that initiates the first …

BACKGROUND The association between diabetes mellitus (DM) and the increased risk and
progression of cholangiocarcinoma (CCA) has been reported with unclear underlying …

Aims Lactic acidosis (LA) generated in tumor microenvironment promotes tumor metastasis
and drug resistance. This study aimed to demonstrate the impacts and the mechanisms of …

Epidemiological studies revealed hyperglycemia as a poor prognostic factor for lung
adenocarcinoma with unclear molecular mechanisms. The present study thus aimed to …

Abstract Aims 5-Fluorouracil (5-FU), a thymidylate synthase (TS) inhibitor, has been used as
the first-line chemotherapeutic drug for cholangiocarcinoma (CCA). The side effects and …

Glioma stem/initiating cells have been considered a major cause of tumor recurrence and
therapeutic resistance. In this study, we have established a new glioma stem-like cell (GSC) …

Introduction Cholangiocarcinoma consists of a cluster of malignant biliary tumors that tend to
have a poor prognosis, ranking as the second most prevalent type of liver cancer, and their …