Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment
Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against
infections and regulates the innate and acquired immune response. IL-18 is produced by …
infections and regulates the innate and acquired immune response. IL-18 is produced by …
Interleukin‐18: Biological properties and role in disease pathogenesis
G Kaplanski - Immunological reviews, 2018 - Wiley Online Library
Initially described as an interferon (IFN) γ‐inducing factor, interleukin (IL)‐18 is indeed
involved in Th1 and NK cell activation, but also in Th2, IL‐17‐producing γδ T cells and …
involved in Th1 and NK cell activation, but also in Th2, IL‐17‐producing γδ T cells and …
The role of inflammatory cytokines as key modulators of neurogenesis
Neurogenesis is an important process in the regulation of brain function and behaviour,
highly active in early development and continuing throughout life. Recent studies have …
highly active in early development and continuing throughout life. Recent studies have …
Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons
Animals susceptible to chronic social defeat stress (CSDS) exhibit depression-related
behaviors, with aberrant transcription across several limbic brain regions, most notably in …
behaviors, with aberrant transcription across several limbic brain regions, most notably in …
Cytokines and C-reactive protein alterations with respect to cognitive impairment in schizophrenia and bipolar disorder: a systematic review
Background The aim of this article was to perform a systematic review of studies
investigating the association between peripheral levels of cytokines and C-reactive protein …
investigating the association between peripheral levels of cytokines and C-reactive protein …
[HTML][HTML] Balance between Interleukin-18 and Interleukin-18 binding protein in auto-inflammatory diseases
M Harel, S Fauteux-Daniel, C Girard-Guyonvarc'h… - Cytokine, 2022 - Elsevier
Abstract Interleukin (IL)-18 is a member of the IL-1 family of cytokines with pleiotropic and
potent pro-inflammatory activities that are tightly controlled at the level of production and in …
potent pro-inflammatory activities that are tightly controlled at the level of production and in …
NLRP3–GABA signaling pathway contributes to the pathogenesis of impulsive-like behaviors and cognitive deficits in aged mice
LY Wang, XP Wang, JM Lv, YD Shan, SY Jia… - Journal of …, 2023 - Springer
Background Perioperative neurocognitive disorders (PND), such as delirium and cognitive
impairment, are commonly encountered complications in aged patients. The inhibitory …
impairment, are commonly encountered complications in aged patients. The inhibitory …
Non‐psychotropic Cannabis sativa L. phytocomplex modulates microglial inflammatory response through CB2 receptors‐, endocannabinoids‐, and NF‐κB‐mediated …
Cannabis sativa L. is increasingly emerging for its protective role in modulating
neuroinflammation, a complex process orchestrated among others by microglia, the resident …
neuroinflammation, a complex process orchestrated among others by microglia, the resident …
TNFα and IL-1β but not IL-18 suppresses hippocampal long-term potentiation directly at the synapse
CNS inflammatory responses are linked to cognitive impairment in humans. Research in
animal models supports this connection by showing that inflammatory cytokines suppress …
animal models supports this connection by showing that inflammatory cytokines suppress …
Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral …
ME de Sousa Rodrigues, M Bekhbat… - Brain, Behavior, and …, 2017 - Elsevier
The mechanisms underlying the association between chronic psychological stress,
development of metabolic syndrome (MetS), and behavioral impairment in obesity are …
development of metabolic syndrome (MetS), and behavioral impairment in obesity are …