The epigenetics orchestra of Notch signaling: a symphony for cancer therapy
A Paniri, MM Hosseini, F Amjadi-Moheb… - …, 2023 - Taylor & Francis
The aberrant regulation of the Notch signaling pathway, which is a fundamental
developmental pathway, has been implicated in a wide range of human cancers. The Notch …
developmental pathway, has been implicated in a wide range of human cancers. The Notch …
Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain
Intellectual disability is a well-known hallmark of Down Syndrome (DS) that results from the
triplication of the critical region of human chromosome 21 (HSA21). Major studies were …
triplication of the critical region of human chromosome 21 (HSA21). Major studies were …
The extracellular matrix molecule tenascin-C modulates cell cycle progression and motility of adult neural stem/progenitor cells from the subependymal zone
E Schaberg, M Götz, A Faissner - Cellular and Molecular Life Sciences, 2022 - Springer
Adult neurogenesis has been described in two canonical regions of the adult central
nervous system (CNS) of rodents, the subgranular zone (SGZ) of the hippocampus and the …
nervous system (CNS) of rodents, the subgranular zone (SGZ) of the hippocampus and the …
Human cytomegalovirus IE2 protein disturbs brain development by the dysregulation of neural stem cell maintenance and the polarization of migrating neurons
Despite the high incidence of severe defects in the central nervous system caused by
human cytomegalovirus (HCMV) congenital infection, the mechanism of HCMV …
human cytomegalovirus (HCMV) congenital infection, the mechanism of HCMV …
Targeted inhibition of leucine-rich repeat and immunoglobulin domain-containing protein 1 in transplanted neural stem cells promotes neuronal differentiation and …
N Chen, J Cen, J Wang, G Qin, L Long… - Critical care …, 2016 - journals.lww.com
Objective: Leucine-rich repeat and immunoglobulin domain-containing protein (LINGO)-1 is
expressed in neural stem cells, and its neutralization results in sustained neuronal …
expressed in neural stem cells, and its neutralization results in sustained neuronal …
Astrocyte‐produced leukemia inhibitory factor expands the neural stem/progenitor pool following perinatal hypoxia–ischemia
RJ Felling, MV Covey, P Wolujewicz… - Journal of …, 2016 - Wiley Online Library
Brain injuries, such as cerebral hypoxia–ischemia (H‐I), induce a regenerative response
from the neural stem/progenitors (NSPs) of the subventricular zone (SVZ); however, the …
from the neural stem/progenitors (NSPs) of the subventricular zone (SVZ); however, the …
PACT increases mammalian embryonic neural stem cell properties by facilitating activation of the notch signaling pathway
SH Byun, M Kwon, SM Lee, H Noh, K Yoon - Biochemical and biophysical …, 2019 - Elsevier
The protein activator of protein kinase R (PKR)(PACT) is known to play important roles in
PKR regulation and microRNA biogenesis. Based on the observation that PACT is …
PKR regulation and microRNA biogenesis. Based on the observation that PACT is …
TRBP maintains mammalian embryonic neural stem cell properties by acting as a novel transcriptional coactivator of the Notch signaling pathway
Transactivation response element RNA-binding protein (TRBP; TARBP2) is known to play
important roles in human immunodeficiency virus (HIV) replication and microRNA …
important roles in human immunodeficiency virus (HIV) replication and microRNA …
Cell Tracking of Adult Neural Stem Cells From The Subependymal Zone In Vitro Reveals Cell Type-Specific Impacts On Cell Cycle Progression By The Extracellular …
E Schaberg, M Götz, A Faissner - 2021 - researchsquare.com
Adult neurogenesis has been described in two canonical regions of the adult central
nervous system (CNS) of rodents, the subgranular zone (SGZ) of the hippocampus and the …
nervous system (CNS) of rodents, the subgranular zone (SGZ) of the hippocampus and the …
Characterizing NOTCH1 PEST domain mutations in Triple Negative Breast Cancer
KC Cravero - 2019 - jscholarship.library.jhu.edu
About 20% of newly diagnosed breast cancers are classified as triple negative breast cancer
(TNBC). These tumors are very heterogenous in nature, and as the name implies, lack …
(TNBC). These tumors are very heterogenous in nature, and as the name implies, lack …