Phage display and other peptide display technologies
W Jaroszewicz, J Morcinek-Orłowska… - FEMS Microbiology …, 2022 - academic.oup.com
Phage display technology, which is based on the presentation of peptide sequences on the
surface of bacteriophage virions, was developed over 30 years ago. Improvements in phage …
surface of bacteriophage virions, was developed over 30 years ago. Improvements in phage …
[HTML][HTML] Advances in antibody phage display technology
Phage display technology can be used for the discovery of antibodies for research,
diagnostic, and therapeutic purposes. In this review, we present and discuss key parameters …
diagnostic, and therapeutic purposes. In this review, we present and discuss key parameters …
Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes
Snakebite envenoming continues to claim many lives across the globe, necessitating the
development of improved therapies. To this end, broadly-neutralizing human monoclonal …
development of improved therapies. To this end, broadly-neutralizing human monoclonal …
Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper
CV Sørensen, J Fernández, AC Adams… - Nature …, 2024 - nature.com
Improved therapies are needed against snakebite envenoming, which kills and permanently
disables thousands of people each year. Recently developed neutralizing monoclonal …
disables thousands of people each year. Recently developed neutralizing monoclonal …
[HTML][HTML] Clinical management of snakebite envenoming: future perspectives
Snakebite envenoming is a major cause of morbidity and mortality in rural communities
throughout the tropics. Generally, the main clinical features of snakebites are local swelling …
throughout the tropics. Generally, the main clinical features of snakebites are local swelling …
[HTML][HTML] Strategies for heterologous expression, synthesis, and purification of animal venom toxins
E Rivera-de-Torre, C Rimbault, TP Jenkins… - … in bioengineering and …, 2022 - frontiersin.org
Animal venoms are complex mixtures containing peptides and proteins known as toxins,
which are responsible for the deleterious effect of envenomations. Across the animal …
which are responsible for the deleterious effect of envenomations. Across the animal …
Terrestrial venomous animals, the envenomings they cause, and treatment perspectives in the Middle East and North Africa
The Middle East and Northern Africa, collectively known as the MENA region, are inhabited
by a plethora of venomous animals that cause up to 420,000 bites and stings each year. To …
by a plethora of venomous animals that cause up to 420,000 bites and stings each year. To …
[HTML][HTML] Towards better antivenoms: navigating the road to new types of snakebite envenoming therapies
Snakebite envenoming is a significant global health challenge, and for over a century,
traditional plasma-derived antivenoms from hyperimmunized animals have been the primary …
traditional plasma-derived antivenoms from hyperimmunized animals have been the primary …
In Vitro Tests for Assessing the Neutralizing Ability of Snake Antivenoms: Toward the 3Rs Principles
There is an urgent need to strengthen the implementation of the 3Rs principle
(Replacement, Reduction and Refinement) in the use of experimental animals in …
(Replacement, Reduction and Refinement) in the use of experimental animals in …
Recent advancements in snake antivenom production
AS Rathore, R Kumar, OS Tiwari - International journal of biological …, 2023 - Elsevier
Snakebite envenoming (SBE), a neglected tropical disease, claims lives of about 138,000
people globally, and antivenom is the only approved treatment worldwide. However, this …
people globally, and antivenom is the only approved treatment worldwide. However, this …