Phage display and other peptide display technologies

W Jaroszewicz, J Morcinek-Orłowska… - FEMS Microbiology …, 2022 - academic.oup.com
Phage display technology, which is based on the presentation of peptide sequences on the
surface of bacteriophage virions, was developed over 30 years ago. Improvements in phage …

[HTML][HTML] Advances in antibody phage display technology

L Ledsgaard, A Ljungars, C Rimbault, CV Sørensen… - Drug Discovery …, 2022 - Elsevier
Phage display technology can be used for the discovery of antibodies for research,
diagnostic, and therapeutic purposes. In this review, we present and discuss key parameters …

Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes

L Ledsgaard, J Wade, TP Jenkins, K Boddum… - Nature …, 2023 - nature.com
Snakebite envenoming continues to claim many lives across the globe, necessitating the
development of improved therapies. To this end, broadly-neutralizing human monoclonal …

Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper

CV Sørensen, J Fernández, AC Adams… - Nature …, 2024 - nature.com
Improved therapies are needed against snakebite envenoming, which kills and permanently
disables thousands of people each year. Recently developed neutralizing monoclonal …

[HTML][HTML] Clinical management of snakebite envenoming: future perspectives

M Hamza, C Knudsen, CA Gnanathasan, W Monteiro… - Toxicon: X, 2021 - Elsevier
Snakebite envenoming is a major cause of morbidity and mortality in rural communities
throughout the tropics. Generally, the main clinical features of snakebites are local swelling …

[HTML][HTML] Strategies for heterologous expression, synthesis, and purification of animal venom toxins

E Rivera-de-Torre, C Rimbault, TP Jenkins… - … in bioengineering and …, 2022 - frontiersin.org
Animal venoms are complex mixtures containing peptides and proteins known as toxins,
which are responsible for the deleterious effect of envenomations. Across the animal …

Terrestrial venomous animals, the envenomings they cause, and treatment perspectives in the Middle East and North Africa

TP Jenkins, S Ahmadi, MA Bittenbinder… - PLoS neglected …, 2021 - journals.plos.org
The Middle East and Northern Africa, collectively known as the MENA region, are inhabited
by a plethora of venomous animals that cause up to 420,000 bites and stings each year. To …

[HTML][HTML] Towards better antivenoms: navigating the road to new types of snakebite envenoming therapies

S Thumtecho, NJ Burlet, A Ljungars… - Journal of Venomous …, 2023 - SciELO Brasil
Snakebite envenoming is a significant global health challenge, and for over a century,
traditional plasma-derived antivenoms from hyperimmunized animals have been the primary …

In Vitro Tests for Assessing the Neutralizing Ability of Snake Antivenoms: Toward the 3Rs Principles

JM Gutiérrez, M Vargas, Á Segura, M Herrera… - Frontiers in …, 2021 - frontiersin.org
There is an urgent need to strengthen the implementation of the 3Rs principle
(Replacement, Reduction and Refinement) in the use of experimental animals in …

Recent advancements in snake antivenom production

AS Rathore, R Kumar, OS Tiwari - International journal of biological …, 2023 - Elsevier
Snakebite envenoming (SBE), a neglected tropical disease, claims lives of about 138,000
people globally, and antivenom is the only approved treatment worldwide. However, this …