Transdifferentiation of epithelial cells into cells with mesenchymal properties and
appearance, that is, epithelial–mesenchymal transition (EMT), is essential during …

The canonical WNT/β-catenin signaling pathway governs a myriad of biological processes
underlying the development and maintenance of adult tissue homeostasis, including …

Bone morphogenetic proteins (BMPs) are cytokines belonging to the transforming growth
factor-β (TGF-β) superfamily. They play multiple functions during development and tissue …

Abstract Glycogen synthase kinase-3 (GSK-3) is associated with various key biological
processes, including glucose regulation, apoptosis, protein synthesis, cell signaling, cellular …

INTRODUCTION Cardiac progenitor cells are multipotent, and lineage analyses of murine
and chick cardiac development have demonstrated that these cells give rise to the cardiac …

Understanding how cells integrate multiple signaling pathways to achieve specific cell
differentiation is a challenging question in cell biology. We have explored the physiological …

The heart is the first functioning organ in the developing embryo and a detailed
understanding of the molecular and cellular mechanisms involved in its formation provides …

Cells are transplanted to regenerate an organs' parenchyma, but how transplanted
parenchymal cells induce stromal regeneration is elusive. Despite the common use of a …

Gastrulation consists in the dramatic reorganisation of the epiblast, a one-cell thick epithelial
sheet, into a multilayered embryo. In chick, the formation of the internal layers requires the …

During embryonic development, Mesp1 marks the earliest cardiovascular progenitors (CPs)
and promotes their specification, epithelial–mesenchymal transition (EMT), and …