Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …

New insights into the field of iron metabolism within the tumor microenvironment have been
uncovered in recent years. Iron promotes the production of reactive oxygen species, which …

Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors
in the world. The efficacy of immunotherapy usually depends on the interaction of …

Heterogeneity describes the differences among cancer cells within and between tumors. It
refers to cancer cells describing variations in morphology, transcriptional profiles …

Genetic alterations drive tumor onset and progression. However, the cross-talk between
tumor cells and the benign components of the surrounding stroma can also promote the …

Metabolic reprogramming of cancer cells within the tumor microenvironment typically occurs
in response to increased nutritional, translation and proliferative demands. Altered lipid …

Globally with over 10 million deaths per year, cancer is the most transversal disease across
countries, cultures, and ethnicities, affecting both developed and developing regions …

Cholangiocarcinoma is characterized by a poor prognosis with limited treatment and
management options. Chemotherapy using gemcitabine with cisplatin is the only available …

Immunotherapy has revolutionized the management of cancers. At the end of 2018, 1,716
clinical trials assessed regimen that combine program death‐1 (PD‐1)/program death ligand …

Abstract Zinc oxide nanoparticles (ZnO NPs) were prepared by a facile, one-pot, greener
approach using aqueous leaf extract of the medicinal plant Nuna (Morinda tinctoria) and …