IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction
In this Opinion article, we discuss the function of tissues as a crucial checkpoint for the
regulation of effector T cell responses, and the notion that interleukin-15 (IL-15) functions as …
regulation of effector T cell responses, and the notion that interleukin-15 (IL-15) functions as …
IL‐15: a central regulator of celiac disease immunopathology
Summary Interleukin‐15 (IL‐15) exerts many biological functions essential for the
maintenance and function of multiple cell types. Although its expression is tightly regulated …
maintenance and function of multiple cell types. Although its expression is tightly regulated …
Circulating microRNAs as biomarkers for disease staging in multiple sclerosis
Objective MicroRNAs (miRNAs) are single‐stranded, small noncoding RNAs that regulate
gene expression. Because they are stable in serum, they are being developed as …
gene expression. Because they are stable in serum, they are being developed as …
[HTML][HTML] Interleukin-15 (dys) regulation of lymphoid homeostasis: Implications for therapy of autoimmunity and cancer
TA Waldmann, MD Miljkovic, KC Conlon - Journal of Experimental …, 2020 - rupress.org
IL-15, a pleiotropic cytokine, stimulates generation of NK, NK-T, γδ, ILC1, and memory CD8
T cells. IL-15 disorders play pathogenetic roles in organ-specific autoimmune diseases …
T cells. IL-15 disorders play pathogenetic roles in organ-specific autoimmune diseases …
Interleukin-15 in autoimmunity
H Allard-Chamard, HK Mishra, M Nandi, M Mayhue… - Cytokine, 2020 - Elsevier
Abstract Interleukin-15 (IL-15) is a member of the IL-2 family of cytokines, which use receptor
complexes containing the common gamma (γ c) chain for signaling. IL-15 plays important …
complexes containing the common gamma (γ c) chain for signaling. IL-15 plays important …
Role of IL-15 in immune-mediated and infectious diseases
A Di Sabatino, SA Calarota, F Vidali… - Cytokine & growth factor …, 2011 - Elsevier
IL-15 has a broad spectrum of biological activities. It is crucial for the development,
proliferation, survival and differentiation of multiple cells from both innate and adaptive …
proliferation, survival and differentiation of multiple cells from both innate and adaptive …
Contribution of astrocyte-derived IL-15 to CD8 T cell effector functions in multiple sclerosis
P Saikali, JP Antel, CL Pittet, J Newcombe… - The Journal of …, 2010 - journals.aai.org
The contribution of local factors to the activation of immune cells infiltrating the CNS of
patients with multiple sclerosis (MS) remains to be defined. The cytokine IL-15 is pivotal in …
patients with multiple sclerosis (MS) remains to be defined. The cytokine IL-15 is pivotal in …
IL-15 amplifies the pathogenic properties of CD4+ CD28− T cells in multiple sclerosis
Abstract CD4+ CD28− T cells arise through repeated antigenic stimulation and are present
in diseased tissues of patients with various autoimmune disorders, including multiple …
in diseased tissues of patients with various autoimmune disorders, including multiple …
Cellular sources of dysregulated cytokines in relapsing-remitting multiple sclerosis
J Romme Christensen, L Börnsen, D Hesse… - Journal of …, 2012 - Springer
Background Numerous cytokines are implicated in the immunopathogenesis of multiple
sclerosis (MS), but studies are often limited to whole blood (WB) or peripheral blood …
sclerosis (MS), but studies are often limited to whole blood (WB) or peripheral blood …
B cell-derived IL-15 enhances CD8 T cell cytotoxicity and is increased in multiple sclerosis patients
Multiple lines of evidence suggest that CD8 T cells contribute to the pathogenesis of multiple
sclerosis (MS). However, the sources and involvement of cytokines such as IL-15 in …
sclerosis (MS). However, the sources and involvement of cytokines such as IL-15 in …