It has been hypothesized that alterations in the composition of the gut microbiota might be
associated with the onset of certain human pathologies, such as Alzheimer disease, a …

Most non-communicable diseases involve inflammatory changes in one or more vascular
systems, and there is considerable evidence that unliganded iron plays major roles in this …

Alzheimer's disease (AD) is a neurodegenerative disorder in which vascular pathology plays
an important role. Since the β-amyloid peptide (Aβ) is a critical factor in this disease, we …

The notion that microvascular abnormalities contribute to deleterious changes in the
Alzheimer's disease (AD) brain is supported by work from our laboratory and others …

In brain physiology, cerebrovascular interactions regulate both, vascular functions, such as
blood vessel branching and endothelial cell homeostasis, as well as neuronal functions …

Tissue-type plasminogen activator (tPA) regulates fibrin clot lysis by stimulating the
conversion of plasminogen into the active protease plasmin [1]. Fibrin is required for efficient …

The increased levels of extracellular DNA found in a number of disorders involving
dysregulation of the fibrinolytic system may affect interactions between fibrinolytic enzymes …

This study investigates the age associated changes in hemorheological properties and
cerebral blood flow. Partial correlations indicate that part of the age-dependent decrease in …

Fibrinogen is a unique protein that is converted into an insoluble fibrin in a single enzymatic
event, which is a characteristic feature of fibrinogen due to its susceptibility to fibrinolytic …

Introduction: Unliganded iron both contributes to the pathology of Alzheimer's disease (AD)
and also changes the morphology of erythrocytes (RBCs). We tested the hypothesis that …