The mammalian proprotein convertases constitute a family of nine secretory serine
proteases that are related to bacterial subtilisin and yeast kexin. Seven of these (proprotein …

Limited endoproteolysis of inactive precursor proteins at sites marked by paired or multiple
basic amino acids is a widespread process by which biologically active peptides and …

Proproteins and prohormones are the fundamental units from which bioactive proteins and
peptides as well as neuropeptides are derived by limited proteolysis within the secretory …

In order to define the enzymes responsible for the maturation of the precursors of brain‐
derived neurotrophic factor (proBDNF) and neurotrophin‐3 (proNT3), we have analysed …

The mammalian secretory proprotein convertases are part of a family of nine serine
proteinases of the subtilisin-type. Seven of them cleave after basic amino acids and are …

In order to define the enzymes responsible for the maturation of the precursor of nerve
growth factor (proNGF), its biosynthesis and intracellular processing by the pro-protein …

We report the role of one member of a novel gene family, PACS-1, in the localization of trans-
Golgi network (TGN) membrane proteins. PACS-1 directs the TGN localization of furin by …

Among the proprotein-processing subtilisin-related endoproteases, furin has been a leading
candidate for the enzyme that activates the hemagglutinin (HA) of virulent avian influenza …

The novel transmembrane aspartic protease BACE (for Beta-site APP CleavingEnzyme) is
the β-secretase that cleaves amyloid precursor protein to initiate β-amyloid formation. As …

Six mammalian processing enzymes were recently discovered which exhibit significant
similarities to both yeast kexin and bacterial subtilisins. These subtilisin/kexin-like …