Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …

The past few decades have witnessed a huge leap forward in our understanding of the
mechanistic underpinnings of pain, in normal states where it helps protect from injury, and …

It is well-recognized that, despite similar pain characteristics, some people with chronic pain
recover, whereas others do not. In this review, we discuss possible contributions and …

After nerve injury maladaptive changes can occur in injured sensory neurons and along the
entire nociceptive pathway within the CNS, which may lead to spontaneous pain or pain …

To paraphrase Cole Porter's famous 1926 song,“What is this thing called pain? This funny
thing called pain, just who can solve its mystery?” Pain, like love, is all consuming: when you …

Postamputation pain (PAP) is highly prevalent after limb amputation but remains an
extremely challenging pain condition to treat. A large part of its intractability stems from the …

Temporomandibular disorders (TMD) consist of a heterogeneous family of musculoskeletal
disorders that represent the most common chronic orofacial pain condition. 15, 16, 57 …

Persistent pain is a sequela of several neurological conditions with a primary immune basis,
such as Guillain-Barré syndrome and multiple sclerosis. Additionally, diverse forms of injury …

BACKGROUND: Many clinical trials have demonstrated the effectiveness of gabapentin and
pregabalin administration in the perioperative period as an adjunct to reduce acute …

Dry eye is a common, multifactorial disease currently diagnosed by a combination of
symptoms and signs. Its epidemiology and clinical presentation have many similarities with …