Proteomics of the Heart

OA Karpov, A Stotland, K Raedschelders… - Physiological …, 2024 - journals.physiology.org
Mass spectrometry-based proteomics is a sophisticated identification tool specializing in
portraying protein dynamics at a molecular level. Proteomics provides biologists with a …

14–3-3ε: a protein with complex physiology function but promising therapeutic potential in cancer

Y Zhang, M Yan, Y Yu, J Wang, Y Jiao, M Zheng… - Cell Communication and …, 2024 - Springer
Over the past decade, the role of the 14–3-3 protein has received increasing interest. Seven
subtypes of 14–3-3 proteins exhibit high homology; however, each subtype maintains its …

Reprogramming of cardiac phosphoproteome, proteome, and transcriptome confers resilience to chronic adenylyl cyclase-driven stress

JH Qu, K Chakir, KV Tarasov, DR Riordon, MG Perino… - Elife, 2024 - elifesciences.org
Our prior study (Tarasov et al., 2022) discovered that numerous adaptive mechanisms
emerge in response to cardiac-specific overexpression of adenylyl cyclase type 8 (TGAC8) …

Functional Genomics and Network Biology

A Joshi, A Kumar, V Kaushik - Advances in Bioinformatics, 2024 - Springer
Functional genomics and network biology have emerged as interdisciplinary fields that
provide a comprehensive understanding of biological systems. This discussion explored …

Shared Proteins and Pathways of Cardiovascular and Cognitive Diseases: Relation to Vascular Cognitive Impairment

ME Zeylan, S Senyuz, P Picon-Pages… - Journal of Proteome …, 2024 - ACS Publications
One of the primary goals of systems medicine is the detection of putative proteins and
pathways involved in disease progression and pathological phenotypes. Vascular cognitive …

The reprogrammed mouse heart phosphoproteome in response to the chronic stress of markedly high cardiac-specific adenylyl cyclase type 8 overexpression

JH Qu, K Chakir, KV Tarasov, DR Riordon, MG Perino… - bioRxiv, 2022 - biorxiv.org
An appropriate intensity and duration of increased AC-cAMP-PKA-Ca2+ signaling is the
quintessential component of acute adaptation to cardiac stress. Our previous work …

Unveiling YWHAH: A potential therapeutic target for overcoming CD8+ T cell exhaustion in colorectal cancer

Q Li, Z Yuan, Y Wang, P Zhai, J Wang, C Zhang… - International …, 2024 - Elsevier
Colorectal cancer (CRC) is a significant global health challenge, with increasing rates of
incidence and mortality. Despite advancements in immunotherapy, resistance, particularly …

ANKRD55 interacts with an IFT-B-like complex in microglia

J Mena, RT Navarro, J Diez-Garcia, M Azkargorta… - bioRxiv, 2024 - biorxiv.org
Introduction: SNPs associated with genome-wide risk for multiple sclerosis (MS) modulate
expression of ankyrin repeat domain protein 55 (ANKRD55). The function of ANKRD55 is …

[HTML][HTML] 14-3-3ζ regulates adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation

SA Rial, Z You, A Vivoli, D Sean, A Al-Khoury, G Lavoie… - bioRxiv, 2024 - ncbi.nlm.nih.gov
We previously established the scaffold protein 14-3-3ζ as a critical regulator of adipogenesis
and adiposity, but the temporal specificity of its action during adipocyte differentiation …

[PDF][PDF] 14-3-3 蛋白影响肿瘤放射敏感性的机制研究进展

徐月辰, 汪红艳, 王凡 - 临床内科杂志, 2023 - lcnkzz.com
14⁃3⁃3蛋白影响肿瘤放射敏感性的机制研究进展 Page 1 [DOI]10.3969/j.issn.1001⁃9057.2023.04.022
http:/ /www.lcnkzz.com/CN/10.3969/j.issn.1001⁃9057.2023.04.022 ·继续教育园地· 14⁃3⁃3蛋白 …