Research on matrix metalloproteinases (MMPs) and in particular on gelatinase B, alias MMP-
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …

Matrix metalloproteinases (MMPs) degrade and modify the extracellular matrix (ECM) as
well as cell-ECM and cell-cell contacts, facilitating detachment of epithelial cells from the …

Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The
importance of ECM remodeling to cancer is appreciated; the relevance of stiffening is less …

Matrix metalloproteinases (MMPs) have been implicated in diverse roles in breast cancer
development and progression. While many of the different MMPs expressed in breast cancer …

Little is known about the dynamics of cancer cell death in response to therapy in the tumor
microenvironment. Intravital microscopy of chemotherapy-treated mouse mammary …

The translation of basic research into improved therapies for breast cancer patients requires
relevant preclinical models that incorporate spontaneous metastasis. We have completed a …

Failure due to poor in vivo efficacy is a primary contributor to attrition during the development
of new chemotherapeutics. Lead optimization programs that in their quest for efficacy focus …

Lung malignancy is the foremost cause of cancer-related deaths globally and is frequently
related to long-term tobacco smoking. Recent studies reveal that the expression of matrix …

Matrix metalloproteinases (MMPs) are reputed to cause the inflammatory tissue destruction
characterizing chronic inflammatory diseases and to degrade basement membrane …

A proangiogenic function of tissue-infiltrating monocytes/macrophages has long been
attributed to their matrix metalloproteinase-9 zymogen (proMMP-9). Herein, we evaluated …