DNA sequencing has revolutionized medicine over recent decades. However, analysis of
large structural variation and repetitive DNA, a hallmark of human genomes, has been …

Advances in DNA sequencing technology have sparked a genomics revolution, driving
breakthroughs in plant genetics and crop breeding. Recently, the focus has shifted from …

Einkorn (Triticum monococcum) was the first domesticated wheat species, and was central
to the birth of agriculture and the Neolithic Revolution in the Fertile Crescent around 10,000 …

Chemical modifications to nucleic acids occur across the kingdoms of life and carry
important regulatory information. Reliable high-resolution mapping of these modifications is …

Wild wheat relatives have been explored in plant breeding to increase the genetic diversity
of bread wheat, one of the most important food crops. Aegilops umbellulata is a diploid U …

Epigenetic modifications play a vital role in the preservation of genome integrity and in the
regulation of gene expression. DNA methylation, one of the key mechanisms of epigenetic …

Long-read sequencing platforms provide unparalleled access to the structure and
composition of all classes of tandemly repeated DNA from STRs to satellite arrays. This …

Innovations in sequencing technology have led to the discovery of novel mutations that
cause inherited diseases. However, many patients with suspected genetic diseases remain …

Background Long-read sequencing can enable the detection of base modifications, such as
CpG methylation, in single molecules of DNA. The most commonly used methods for long …

Wheat (Triticum aestivum) is one of the most important food crops with an urgent need for
increase in its production to feed the growing world. Triticum timopheevii (2n= 4x= 28) is an …