Nasopharyngeal carcinoma: an evolving paradigm

KCW Wong, EP Hui, KW Lo, WKJ Lam… - Nature reviews Clinical …, 2021 - nature.com
The past three decades have borne witness to many advances in the understanding of the
molecular biology and treatment of nasopharyngeal carcinoma (NPC), an Epstein–Barr virus …

Treating head and neck cancer in the age of immunotherapy: a 2023 update

A Bhatia, B Burtness - Drugs, 2023 - Springer
Most patients diagnosed with head and neck squamous cell carcinoma (HNSCC) will
present with locally advanced disease, requiring multimodality therapy. While this approach …

The Chinese Society of Clinical Oncology (CSCO) clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma

LL Tang, YP Chen, CB Chen, MY Chen… - Cancer …, 2021 - Wiley Online Library
Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor originating in the
nasopharynx and has a high incidence in Southeast Asia and North Africa. To develop these …

Chemotherapy in combination with radiotherapy for definitive-intent treatment of stage II-IVA nasopharyngeal carcinoma: CSCO and ASCO guideline

YP Chen, N Ismaila, MLK Chua, AD Colevas… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE The aim of this joint guideline is to provide evidence-based recommendations to
practicing physicians and other healthcare providers on definitive-intent chemoradiotherapy …

WTAP-mediated m6A modification of lncRNA DIAPH1-AS1 enhances its stability to facilitate nasopharyngeal carcinoma growth and metastasis

ZX Li, ZQ Zheng, PY Yang, L Lin, GQ Zhou… - Cell Death & …, 2022 - nature.com
As the most predominant RNA epigenetic regulation in eukaryotic cells, N6-
methyladenosine (m6A) plays a critical role in human tumorigenesis and cancer …

Gemcitabine and cisplatin induction chemotherapy in nasopharyngeal carcinoma

Y Zhang, L Chen, GQ Hu, N Zhang… - … England Journal of …, 2019 - Mass Medical Soc
Background Platinum-based concurrent chemoradiotherapy is the standard of care for
patients with locoregionally advanced nasopharyngeal carcinoma. Additional gemcitabine …

Metronomic capecitabine as adjuvant therapy in locoregionally advanced nasopharyngeal carcinoma: a multicentre, open-label, parallel-group, randomised …

YP Chen, X Liu, Q Zhou, KY Yang, F Jin, XD Zhu, M Shi… - The Lancet, 2021 - thelancet.com
Background Patients with locoregionally advanced nasopharyngeal carcinoma have a high
risk of disease relapse, despite a high proportion of patients attaining complete clinical …

[HTML][HTML] Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution

Y Liu, S He, XL Wang, W Peng, QY Chen… - Nature …, 2021 - nature.com
The heterogeneous nature of tumour microenvironment (TME) underlying diverse treatment
responses remains unclear in nasopharyngeal carcinoma (NPC). Here, we profile 176,447 …

NCCN guidelines insights: head and neck cancers, version 1.2018

AD Colevas, SS Yom, DG Pfister, S Spencer… - Journal of the National …, 2018 - jnccn.org
The NCCN Guidelines for Head and Neck (H&N) Cancers provide treatment
recommendations for cancers of the lip, oral cavity, pharynx, larynx, ethmoid and maxillary …

Long noncoding RNA FAM225A promotes nasopharyngeal carcinoma tumorigenesis and metastasis by acting as ceRNA to sponge miR-590-3p/miR-1275 and …

ZQ Zheng, ZX Li, GQ Zhou, L Lin, LL Zhang, JW Lv… - Cancer research, 2019 - AACR
Long noncoding RNAs (lncRNA) play important roles in the tumorigenesis and progression
of cancers. However, the clinical significance of lncRNAs and their regulatory mechanisms …