Oncogenes are activated through well-known chromosomal alterations such as gene fusion,
translocation, and focal amplification. In light of recent evidence that the control of key genes …

In certain human cancers, the expression of critical oncogenes is driven from large
regulatory elements, called super-enhancers, that recruit much of the cell's transcriptional …

Health span is driven by a precise interplay between genes and the environment. Cell
response to environmental cues is mediated by signaling cascades and genetic variants that …

Despite recent advances, the structures of many proteins cannot be determined by electron
cryomicroscopy because the individual proteins move during irradiation. This blurs the …

DNA is compacted into higher order structures that have major implications in gene
regulation. These structures allow for long-range interactions of DNA elements, such as the …

Lineage-specific transcription factors are critical for long-range enhancer interactions, but
direct or indirect contributions of architectural proteins such as CCCTC-binding factor …

While constitutive CCCTC-binding factor (CTCF)–binding sites are needed to maintain
relatively invariant chromatin structures, such as topologically associating domains, the …

TAL1 (SCL/TAL1, T-cell acute leukemia protein 1) is a transcription factor that is involved in
the process of hematopoiesis and leukemogenesis. It participates in blood cell formation …

T-cell acute lymphoblastic leukaemias (T-ALL) are aggressive malignant proliferations
characterized by high relapse rates and great genetic heterogeneity. TAL1 is amongst the …

Recently, whole genome sequencing approaches have pinpointed mutations in genes that
were previously not associated with cancer. For Acute Myeloid Leukaemia (AML), and other …