Principles and methods for transferring polygenic risk scores across global populations
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …
or disease and may become a valuable tool for advancing precision medicine. However …
The future of early cancer detection
A proactive approach to detecting cancer at an early stage can make treatments more
effective, with fewer side effects and improved long-term survival. However, as detection …
effective, with fewer side effects and improved long-term survival. However, as detection …
Breast cancer screening for women at higher-than-average risk: updated recommendations from the ACR
Early detection decreases breast cancer death. The ACR recommends annual screening
beginning at age 40 for women of average risk and earlier and/or more intensive screening …
beginning at age 40 for women of average risk and earlier and/or more intensive screening …
Improving reporting standards for polygenic scores in risk prediction studies
H Wand, SA Lambert, C Tamburro, MA Iacocca… - Nature, 2021 - nature.com
Polygenic risk scores (PRSs), which often aggregate results from genome-wide association
studies, can bridge the gap between initial discovery efforts and clinical applications for the …
studies, can bridge the gap between initial discovery efforts and clinical applications for the …
Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations
Polygenic risk scores (PRSs) have improved in predictive performance, but several
challenges remain to be addressed before PRSs can be implemented in the clinic, including …
challenges remain to be addressed before PRSs can be implemented in the clinic, including …
Prospective validation of the BOADICEA multifactorial breast cancer risk prediction model in a large prospective cohort study
X Yang, M Eriksson, K Czene, A Lee, G Leslie… - Journal of medical …, 2022 - jmg.bmj.com
Background The multifactorial Breast and Ovarian Analysis of Disease Incidence and
Carrier Estimation Algorithm (BOADICEA) breast cancer risk prediction model has been …
Carrier Estimation Algorithm (BOADICEA) breast cancer risk prediction model has been …
Polygenic scores in cancer
Since the publication of the first genome-wide association study for cancer in 2007,
thousands of common alleles that are associated with the risk of cancer have been …
thousands of common alleles that are associated with the risk of cancer have been …
Recent advances in polygenic scores: translation, equitability, methods and FAIR tools
Polygenic scores (PGS) can be used for risk stratification by quantifying individuals' genetic
predisposition to disease, and many potentially clinically useful applications have been …
predisposition to disease, and many potentially clinically useful applications have been …
Proactive breast cancer risk assessment in primary care: a review based on the principles of screening
In the UK, the National Institute for Health and Care Excellence (NICE) recommends that
women at moderate or high risk of breast cancer be offered risk-reducing medication and …
women at moderate or high risk of breast cancer be offered risk-reducing medication and …
Polygenic risk scores, radiation treatment exposures and subsequent cancer risk in childhood cancer survivors
TM Gibson, DM Karyadi, SW Hartley, MA Arnold… - Nature medicine, 2024 - nature.com
Survivors of childhood cancer are at increased risk for subsequent cancers attributable to
the late effects of radiotherapy and other treatment exposures; thus, further understanding of …
the late effects of radiotherapy and other treatment exposures; thus, further understanding of …