Therapeutic strategies for hepatitis B virus infection: towards a cure
GC Fanning, F Zoulim, J Hou, A Bertoletti - Nature reviews Drug …, 2019 - nature.com
Chronic hepatitis B virus (HBV) infection is a common cause of liver disease globally, with a
disproportionately high burden in South-East Asia. Vaccines and nucleoside or nucleotide …
disproportionately high burden in South-East Asia. Vaccines and nucleoside or nucleotide …
The immune tolerant phase of chronic HBV infection: new perspectives on an old concept
A Bertoletti, PT Kennedy - Cellular & molecular immunology, 2015 - nature.com
Chronic hepatitis B virus (HBV) infection progresses through distinct disease phases that are
strongly associated with patient age. The so-called immune tolerant (IT) phase represents …
strongly associated with patient age. The so-called immune tolerant (IT) phase represents …
[HTML][HTML] Structural insights into the HBV receptor and bile acid transporter NTCP
Around 250 million people are infected with hepatitis B virus (HBV) worldwide, and 15
million may also carry the satellite virus hepatitis D virus (HDV), which confers even greater …
million may also carry the satellite virus hepatitis D virus (HDV), which confers even greater …
[HTML][HTML] The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus
S Sato, K Li, T Kameyama, T Hayashi, Y Ishida… - Immunity, 2015 - cell.com
Host innate recognition triggers key immune responses for viral elimination. The sensing
mechanism of hepatitis B virus (HBV), a DNA virus, and the subsequent downstream …
mechanism of hepatitis B virus (HBV), a DNA virus, and the subsequent downstream …
HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production
X Yu, P Lan, X Hou, Q Han, N Lu, T Li, C Jiao… - Journal of …, 2017 - Elsevier
Background & Aims Hepatitis B virus (HBV) has developed strategies to evade immune
responses. However, the mechanisms involved remain unclear. The NLRP3 inflammasome …
responses. However, the mechanisms involved remain unclear. The NLRP3 inflammasome …
[HTML][HTML] Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP
M Iwamoto, K Watashi, S Tsukuda, HH Aly… - Biochemical and …, 2014 - Elsevier
Hepatitis B virus (HBV) entry has been analyzed using infection-susceptible cells, including
primary human hepatocytes, primary tupaia hepatocytes, and HepaRG cells. Recently, the …
primary human hepatocytes, primary tupaia hepatocytes, and HepaRG cells. Recently, the …
[PDF][PDF] Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate …
K Watashi, A Sluder, T Daito, S Matsunaga, A Ryo… - …, 2014 - Wiley Online Library
Chronic hepatitis B virus (HBV) infection is a major public health problem worldwide.
Although nucleos (t) ide analogs inhibiting viral reverse transcriptase are clinically available …
Although nucleos (t) ide analogs inhibiting viral reverse transcriptase are clinically available …
[HTML][HTML] Galectin-9 restricts hepatitis B virus replication via p62/SQSTM1-mediated selective autophagy of viral core proteins
K Miyakawa, M Nishi, M Ogawa, S Matsunaga… - Nature …, 2022 - nature.com
Autophagy has been linked to a wide range of functions, including a degradative process
that defends host cells against pathogens. Although the involvement of autophagy in HBV …
that defends host cells against pathogens. Although the involvement of autophagy in HBV …
[HTML][HTML] Immunotherapy for chronic hepatitis B virus infection
A Bertoletti, N Le Bert - Gut and liver, 2018 - ncbi.nlm.nih.gov
While new therapies for chronic hepatitis C virus infection have delivered remarkable cure
rates, curative therapies for chronic hepatitis B virus (HBV) infection remain a distant goal …
rates, curative therapies for chronic hepatitis B virus (HBV) infection remain a distant goal …
[HTML][HTML] Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus
K Kitamura, L Que, M Shimadu, M Koura… - PLoS …, 2018 - journals.plos.org
Hepatitis B virus (HBV) is one of the major etiological pathogens for liver cirrhosis and
hepatocellular carcinoma. Chronic HBV infection is a key factor in these severe liver …
hepatocellular carcinoma. Chronic HBV infection is a key factor in these severe liver …