Turning'sweet'on immunity: galectin–glycan interactions in immune tolerance and inflammation

GA Rabinovich, MA Toscano - Nature Reviews Immunology, 2009 - nature.com
The function of deciphering the biological information encoded by the glycome, which is the
entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in …

Galectins: regulators of acute and chronic inflammation

FT Liu, GA Rabinovich - Annals of the New York Academy of …, 2010 - Wiley Online Library
Galectins, β‐galactoside‐binding animal lectins, are differentially expressed by various
immune cells as well as a wide range of other cell types. Extracellularly, galectins are able to …

When galectins recognize glycans: from biochemistry to physiology and back again

S Di Lella, V Sundblad, JP Cerliani, CM Guardia… - Biochemistry, 2011 - ACS Publications
In the past decade, increasing efforts have been devoted to the study of galectins, a family of
evolutionarily conserved glycan-binding proteins with multifunctional properties. Galectins …

Glycosylation in immune cell trafficking

M Sperandio, CA Gleissner, K Ley - Immunological reviews, 2009 - Wiley Online Library
Leukocyte recruitment encompasses cell adhesion and activation steps that enable
circulating leukocytes to roll, arrest, and firmly adhere on the endothelial surface before they …

The universe of galectin-binding partners and their functions in health and disease

MF Troncoso, MT Elola, AG Blidner, L Sarrias… - Journal of Biological …, 2023 - ASBMB
Galectins, a family of evolutionarily conserved glycan-binding proteins, play key roles in
diverse biological processes including tissue repair, adipogenesis, immune cell …

The interplay of galectins-1,-3, and-9 in the immune-inflammatory response underlying cardiovascular and metabolic disease

AA Mansour, F Krautter, Z Zhi, AJ Iqbal… - Cardiovascular …, 2022 - Springer
Galectins are β-galactoside-binding proteins that bind and crosslink molecules via their
sugar moieties, forming signaling and adhesion networks involved in cellular …

Galectins in acute and chronic inflammation

FT Liu, RY Yang, DK Hsu - Annals of the New York Academy of …, 2012 - Wiley Online Library
Galectins are animal lectins that bind to β‐galactosides, such as lactose and N‐
acetyllactosamine, in free form or contained in glycoproteins or glycolipids. They are located …

Galectin-8 in the onset of the immune response and inflammation

MV Tribulatti, J Carabelli, CA Prato… - Glycobiology, 2020 - academic.oup.com
Galectins (Gals), a family of mammalian lectins, have emerged as key regulators of the
immune response, being implicated in several physiologic and pathologic conditions. Lately …

[HTML][HTML] Galectin-9 supports primary T cell transendothelial migration in a glycan and integrin dependent manner

AA Mansour, F Raucci, M Sevim, A Saviano… - Biomedicine & …, 2022 - Elsevier
Adaptive immunity relies on the efficient recruitment of T cells from the blood into peripheral
tissues. However, the current understanding of factor (s) coordinating these events is …

Membrane organization by tetraspanins and galectins shapes lymphocyte function

L Querol Cano, VME Dunlock… - Nature Reviews …, 2024 - nature.com
Immune receptors are not randomly distributed at the plasma membrane of lymphocytes but
are segregated into specialized domains that function as platforms to initiate signalling, as …