Microbial membrane transport proteins and their biotechnological applications
Because of the hydrophobic nature of the membrane lipid bilayer, the majority of the
hydrophilic solutes require special transportation mechanisms for passing through the cell …
hydrophilic solutes require special transportation mechanisms for passing through the cell …
Advances in methods and concepts provide new insight into antibiotic fluxes across the bacterial membrane
J Vergalli, M Réfrégiers, P Ruggerone… - Communications …, 2024 - nature.com
The sophisticated envelope of Gram-negative bacteria modulates the uptake of small
molecules in a side-chain-sensitive manner. Despite intensive theoretical and experimental …
molecules in a side-chain-sensitive manner. Despite intensive theoretical and experimental …
Converging PMF Calculations of Antibiotic Permeation across an Outer Membrane Porin with Subkilocalorie per Mole Accuracy
J Lapierre, JS Hub - Journal of Chemical Information and …, 2023 - ACS Publications
The emergence of multidrug-resistant pathogens led to a critical need for new antibiotics. A
key property of effective antibiotics against Gram-negative bacteria is their ability to …
key property of effective antibiotics against Gram-negative bacteria is their ability to …
Machine Learning Prediction of Small Molecule Accumulation in Escherichia Coli Enhanced with Descriptor Statistics
S Milenkovic, S Boi, MA Scorciapino… - Journal of Chemical …, 2024 - ACS Publications
Antibiotic resistance, particularly among Gram-negative bacteria, poses a significant
healthcare challenge due to their ability to evade antibiotic action through various …
healthcare challenge due to their ability to evade antibiotic action through various …
Seeing is believing: Illuminating the Gram-negative outer membrane with molecular dynamics simulations
Recent advances in molecular dynamics (MD) simulations have led to rapid improvement in
our understanding of the molecular details of the outer membranes (OMs) of Gram-negative …
our understanding of the molecular details of the outer membranes (OMs) of Gram-negative …
The mechanism of an electrostatic nanofilter: overcoming entropy with electrostatics
I Bodrenko, M Ceccarelli… - Physical Chemistry …, 2023 - pubs.rsc.org
General porins are nature's sieving machinery in the outer membrane of Gram-negative
bacteria. Their unique hourglass-shaped architecture is highly conserved among different …
bacteria. Their unique hourglass-shaped architecture is highly conserved among different …
The Effect of Lipopolysaccharides on the Electrostatic Properties of Gram‐Negative General Porins from Enterobacteriaceae
We investigated, by using all‐atom molecular dynamics simulations, the effect of the outer
membrane of Gram‐negative bacteria, composed in the outer leaflet by polar/charged …
membrane of Gram‐negative bacteria, composed in the outer leaflet by polar/charged …