The ventilatory control system is highly vulnerable to exogenous administered opioid
analgesics. Particularly respiratory depression is a potentially lethal complication that may …

Strong opioid analgesics are the mainstay of therapy for the relief of moderate to severe
acute nociceptive pain that may occur post-operatively or following major trauma, as well as …

We are developing a series of thiolesters that produce an immediate and sustained reversal
of the deleterious effects of opioids, such as morphine and fentanyl, on ventilation without …

This paper is the thirty-eighth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2015 …

Opioids may produce life-threatening respiratory depression and death from their actions at
the opioid receptors within the brainstem respiratory neuronal network. Since there is an …

Rationale Tianeptine is a mu-opioid receptor (MOR) agonist with increasing reports of abuse
in human populations. Preclinical data regarding the abuse potential and other opioid-like …

Background Animal data suggest that the antidepressant and α-amino-3-hydroxy-5-methyl-4-
isoxazolepropionic acid receptor modulator tianeptine is able to prevent opioid-induced …

Deregulation of synaptic function and neurotransmission has been linked with the
development of major depression disorder (MDD). Tianeptine (Tian) has been used as …

The introduction of the first antidepressants in the 50s of the 20th century radically changed
the treatment of depression, while providing information on pathophysiological aspects of …

Adult male rats exposed to chronic social isolation (CSIS) show depressive-and anxiety-like
behaviors and reduce the numbers of parvalbumin-positive (PV+) interneurons in the dorsal …