Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain
homeostatic functions and mediate pathogenic mechanisms, including the inflammatory …

Major depressive disorder (MDD) is a prevalent and disabling psychiatric disease with rates
of non-responsiveness to antidepressants ranging from 30–50%. Historically, the …

Efferocytosis, the clearance of apoptotic cells (ACs) by macrophages, is critical for tissue
resolution, with defects driving many diseases. Mechanisms of efferocytosis-mediated …

Periodontitis is a chronic inflammatory condition of the periodontium involving interactions
between bacterial products, numerous cell populations and inflammatory mediators. It is …

In conjunction with the classical functions of regulating intestinal, bone, and kidney calcium
and phosphorus absorption, as well as bone mineralization of vitamin D, the population …

Eicosanoids represent a diverse family of lipid mediators with fundamental roles in
physiology and disease. Within the eicosanoid superfamily are prostanoids, which are …

An effective host defense mechanism involves inflammation to eliminate pathogens from the
site of infection, followed by the resolution of inflammation and the restoration of tissue …

Inflammatory pain, such as arthritis pain, is a growing health problem. Inflammatory pain is
generally treated with opioids and cyclooxygenase (COX) inhibitors, but both are limited by …

Cyclooxgenases are key enzymes of lipid signaling. They carry out the first step in the
production of prostaglandins, important mediators of inflammation, pain, cardiovascular …

Endothelium‐dependent contractions contribute to endothelial dysfunction in various animal
models of aging, diabetes and cardiovascular diseases. In the spontaneously hypertensive …