New research has shown that the development of osteoarthritis (OA) is regulated by different
mechanisms of cell death and types of cytokines. Therefore, elucidating the mechanism of …

Pyroptosis and necroptosis represent two pathways of genetically encoded necrotic cell
death. Although these cell death programmes can protect the host against microbial …

Programmed cell death has a vital role in embryonic development and tissue homeostasis.
Necroptosis is an alternative mode of regulated cell death mimicking features of apoptosis …

Ruptured and intact plasma membranes are classically considered as hallmarks of necrotic
and apoptotic cell death, respectively. As such, apoptosis is usually considered a non …

Roles for cell death in development, homeostasis, and the control of infections and cancer
have long been recognized. Although excessive cell damage results in passive necrosis …

Abstract Receptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the
“programmed” and “regulated” cell death pathway called necroptosis. Necroptosis is …

In the early 2000s, receptor-interacting serine/threonine protein kinase 1 (RIPK1), a
molecule already recognized as an important regulator of cell survival, inflammation and …

Necroptosis is a genetically regulated form of necrotic cell death that has emerged as an
important pathway in human disease. The necroptosis pathway is induced by a variety of …

Abstract Necrostatin-1 (Nec-1) is a RIP1-targeted inhibitor of necroptosis, a form of
programmed cell death discovered and investigated in recent years. There are already …

The remarkable plasticity and plethora of biological functions performed by macrophages
have enticed scientists to study these cells in relation to atherosclerosis for> 50 years, and …