A search for molecular mechanisms underlying male idiopathic infertility

A Bracke, K Peeters, U Punjabi, D Hoogewijs… - Reproductive …, 2018 - Elsevier
Infertility affects approximately 15% of the couples wanting to conceive. In 30− 40% of the
cases the aetiology of male infertility remains unknown and is called idiopathic male …

[HTML][HTML] Semen evaluation: Methodological advancements in sperm quality-specific fertility assessment—A review

BM Tanga, AY Qamar, S Raza, S Bang, X Fang… - Animal …, 2021 - ncbi.nlm.nih.gov
Assessment of male fertility is based on the evaluation of sperm. Semen evaluation
measures various sperm quality parameters as fertility indicators. However, semen …

Simulating nature in sperm selection for assisted reproduction

ETY Leung, CL Lee, X Tian, KKW Lam, RHW Li… - Nature Reviews …, 2022 - nature.com
Sperm selection in the female reproductive tract (FRT) is sophisticated. Only about 1,000
sperm out of millions in an ejaculate reach the fallopian tube and thus have a chance of …

Bisphenol AF compromises blood-testis barrier integrity and sperm quality in mice

D Wu, CJ Huang, XF Jiao, ZM Ding, SX Zhang… - Chemosphere, 2019 - Elsevier
The profound influence of environmental chemicals on human health including inducing life-
threatening gene mutation has been publicly recognized. Being a substitute for the …

Hexachlorocyclohexane impairs human sperm motility by affecting lysine glutarylation and mitochondrial functions

L Yang, G Mei, Y Yang, J Cui, S Peng, Z Peng… - Food and Chemical …, 2023 - Elsevier
Decreased sperm motility is a leading cause of male infertility and persistent organic
pollutants are known to contribute significantly to the development of this disease. The …

Cryopreservation of bull semen is associated with carbonylation of sperm proteins

A Mostek, MA Dietrich, M Słowińska, A Ciereszko - Theriogenology, 2017 - Elsevier
Artificial insemination with cryopreserved semen enables affordable, large-scale
dissemination of gametes with superior genetics. However, cryopreservation can cause …

Proteomics and metabolomics—Current and future perspectives in clinical andrology

MK Panner Selvam, R Finelli, A Agarwal… - Andrologia, 2021 - Wiley Online Library
Proteomics and metabolomics are emerging as promising tools to investigate the molecular
mechanisms associated with male infertility. Proteins and metabolites play a pivotal role in …

[HTML][HTML] Cryopreservation induces acetylation of metabolism-related proteins in boar sperm

MA Ali, Z Qin, S Dou, A Huang, Y Wang… - International Journal of …, 2023 - mdpi.com
Cryodamage affects the normal physiological functions and survivability of boar sperm
during cryopreservation. Lysine acetylation is thought to be an important regulatory …

[HTML][HTML] Comparative proteomics and phosphoproteomics analysis reveal the possible breed difference in yorkshire and duroc boar spermatozoa

Y Xu, Q Han, C Ma, Y Wang, P Zhang, C Li… - Frontiers in Cell and …, 2021 - frontiersin.org
Sperm cells are of unique elongated structure and function, the development of which is
tightly regulated by the existing proteins and the posttranslational modifications (PTM) of …

Biological functions and large-scale profiling of protein glycosylation in human semen

R Lan, M Xin, Z Hao, S You, Y Xu, J Wu… - Journal of proteome …, 2020 - ACS Publications
Glycosylation is one of the most important post-translational modifications of proteins and
plays an essential role in spermatogenesis, maturation, extracellular quality control …