Neurological diseases continue to increase in prevalence worldwide. Combined with the
lack of modifiable risk factors or strongly efficacious therapies, these disorders pose a …

The blood–brain barrier (BBB) is a specialized semipermeable structure that highly
regulates exchanges between the central nervous system parenchyma and blood vessels …

Abstract Crossing the Blood Brain Barrier constitutes a challenge in drug administration to
the brain. In this context, nose-to-brain delivery is explored as an alternative route in the …

Introduction Insulin plays a critical role in metabolism modulation including carbohydrate,
lipid, and protein metabolism. There is room to improve insulin delivery but optimizing the …

Background: Site-specific drug delivery is a widespread and demanding area nowadays.
Lipid-based nanoparticulate drug delivery systems have shown promising effects for …

Peptide drugs through nasal mucous membrane, such as insulin and calcitonin have been
widely used in the medical field. There are always two sides to a coin. One side, intranasal …

The incidence of sporadic Alzheimer's disease (AD) is increasing in recent years. Studies
have shown that in addition to some genetic abnormalities, the majority of AD patients has a …

Donepezil nasal delivery strategies are being continuously investigated for advancing
therapy in Alzheimer's disease. The aim of this study was to develop a chitosan-based …

Dopamine is unable to access the central nervous system through the bloodstream. Only its
precursor can do so, and with an effectiveness below 100% of the dose administered, as it is …

The surge in neurological disorders necessitates innovative strategies for delivering active
pharmaceutical ingredients to the brain. The non-invasive intranasal route has emerged as …