G-protein-coupled receptors (GPCRs) remain major drug targets, despite our incomplete
understanding of how they signal through 16 non-visual G-protein signal transducers …

Energy landscape theories have provided a common ground for understanding the protein
folding problem, which once seemed to be overwhelmingly complicated. At the same time …

G protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by mediating a GDP
to GTP exchange in the Gα subunit. This leads to dissociation of the heterotrimer into Gα …

G-Protein-coupled receptors (GPCRs) signal through G protein α and βγ subunit families to
regulate a wide range of physiological and pathophysiological processes. As such, GPCRs …

Heterotrimeric G proteins are molecular switches in GPCR signaling pathways and regulate
a plethora of physiological and pathological processes. GPCRs are efficient drug targets …

Any aspect of cell activity is regulated by extracellular signals that are recognized, decoded,
and transduced inside the cell via different classes of plasma membrane receptors. 1À3 G …

Heterotrimeric G proteins serve as membrane-associated signaling hubs, in concert with
their cognate G-protein-coupled receptors. Fluorine nuclear magnetic resonance …

Nuclear magnetic resonance (NMR) has evolved into a powerful tool for characterizing
protein–ligand interactions in solution under near physiological conditions. It is now …

Heterotrimeric guanine nucleotide-binding proteins (G proteins) composed of three subunits
α, β, γ mediate activation of multiple intracellular signaling cascades initiated by G protein …

The tight complexes FKBP12 forms with immunosuppressive drugs, such as FK506 and
rapamycin, are frequently used as models for developing approaches to structure-based …