Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Kisspeptin is involved in the control of human reproduction bridging the gap between the
sex steroid levels and feedback mechanisms that control the gonadotropin releasing …

Context Congenital hypogonadotropic hypogonadism (CHH) is a rare condition caused by
GnRH deficiency. Several genes have been associated with the pathogenesis of CHH, but …

Congenital hypogonadotropic hypogonadism (CHH) causes pubertal failure and infertility in
both women and men due to partial or total secretory failure of the two pituitary …

Idiopathic hypogonadotropic hypogonadism (IHH) is defined by absent or incomplete
puberty and characterised biochemically by low levels of sex steroids, with low or …

GnRH neurons follow a carefully orchestrated journey from their birth in the olfactory
placode area. Initially, they migrate along with the vomeronasal nerve into the brain at the …

The neuroendocrine regulation of reproduction is an intricate process requiring the exquisite
coordination of an assortment of cellular networks, all converging on the GnRH neurons …

Landmark studies have shown that mutations in kisspeptin and the kisspeptin receptor
(Kiss1r) result in reproductive dysfunction in humans and genetically altered mouse models …

Context: The G protein-coupled receptor 54 (GPR54), the kisspeptin receptor, is essential for
stimulation of GnRH secretion and induction of puberty. Recently loss-of-function mutations …

The goal of this study was to investigate how the Arg386Pro mutation prolongs KiSS-1
receptor (KISS1R) responsiveness to kisspeptin, contributing to human central precocious …