Background Calcium ions are involved in several human cellular processes including
corticogenesis, transcription, and synaptogenesis. Nevertheless, the relationship between …

SNARE-complexes drive the fusion of membrane-bound vesicles with target membranes or
with each other (homotypic fusion). The SNARE-proteins are subdivided into Q a, Q b, Q c …

T-type calcium channels represent a key pathway for Ca 2+ entry near the resting
membrane potential. Increasing evidence supports a unique role of these channels in fast …

Objective To study the position of hemiplegic migraine in the clinical spectrum of migraine
with aura and to reveal the importance of CACNA1A, ATP1A2 and SCN1A in the …

The soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptor
(SNARE) proteins play a central role in most forms of intracellular membrane trafficking, a …

Voltage-gated Ca2+ (CaV) channels enable Ca2+ influx in response to membrane
depolarization. CaV2. 1 channels are localized to the presynaptic membrane of many types …

Human mutations in the CACNA1A gene that encodes the pore-forming α 1A subunit of the
voltage-gated Ca V 2.1 (P/Q-type) Ca 2+ channel cause multiple neurological disorders …

Mucin 5AC (MUC5AC) is secreted by goblet cells of the respiratory tract and, surprisingly,
also expressed de novo in mucus secreting cancer lines. siRNA-mediated knockdown of …

CACNA1A pathogenic variants have been linked to several neurological disorders including
familial hemiplegic migraine and cerebellar conditions. More recently, de novo variants have …

Hemiplegic migraine (HM) is a rare and severe subtype of autosomal dominant migraine,
characterized by a complex aura including some degree of motor weakness. Mutations in …