[HTML][HTML] Thiazole ring—A biologically active scaffold

A Petrou, M Fesatidou, A Geronikaki - Molecules, 2021 - mdpi.com
Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …

[HTML][HTML] The bioactivity of thiazolidin-4-ones: A short review of the most recent studies

D Mech, A Kurowska, N Trotsko - International Journal of Molecular …, 2021 - mdpi.com
Thiazolidin-4-ones is an important heterocyclic ring system of a pharmacophore and a
privileged scaffold in medicinal chemistry. This review is focused on the latest scientific …

[HTML][HTML] Antiviral activity of selected Lamiaceae essential oils and their monoterpenes against SARS-CoV-2

S Ćavar Zeljković, E Schadich, P Džubák… - Frontiers in …, 2022 - frontiersin.org
This study presents the very first report on the in vitro antiviral activity of selected essential
oils of Lamiaceae plant species and their monoterpenes against severe acute respiratory …

[HTML][HTML] Recent progress in the development of indole-based compounds active against malaria, trypanosomiasis and leishmaniasis

PAF Pacheco, MMM Santos - Molecules, 2022 - mdpi.com
Human protozoan diseases represent a serious health problem worldwide, affecting mainly
people in social and economic vulnerability. These diseases have attracted little investment …

Synthetic product-based approach toward potential antileishmanial drug development

R Pal, G Teli, MJ Akhtar, GSP Matada - European Journal of Medicinal …, 2023 - Elsevier
Leishmaniasis is a parasitic disease and is categorized as a tropically neglected disease
(NTD) with no effective vaccines available. The available chemotherapeutics against …

Synthetic and medicinal perspective of antileishmanial agents: an overview

S Pawar, MK Kumawat, M Kundu, K Kumar - Journal of Molecular Structure, 2023 - Elsevier
Leishmaniasis is one of the most common neglected tropical diseases (NTD), and is
originated in over 98 countries, affecting about 12 million people every year, which is …

Synthesis and Biological Screening of New 2-(5-Aryl-1-phenyl-1H-pyrazol-3-yl)-4-aryl Thiazole Derivatives as Potential Antimicrobial Agents

Y Nandurkar, A Shinde, MR Bhoye, S Jagadale… - ACS …, 2023 - ACS Publications
A new series of 2-(5-aryl-1-phenyl-1 H-pyrazol-3-yl)-4-aryl thiazoles (10a–ab) have been
synthesized by a cyclocondensation reaction of 5-aryl-1-phenyl-1 H-pyrazole-3 …

[HTML][HTML] Synthesis, Characterization and In Vitro Evaluation of Novel 5-Ene-thiazolo[3,2-b][1,2,4]triazole-6(5H)-ones as Possible Anticancer Agents

S Holota, S Komykhov, S Sysak, A Gzella, A Cherkas… - Molecules, 2021 - mdpi.com
The present paper is devoted to the search for drug-like molecules with anticancer
properties using the thiazolo [3, 2-b][1, 2, 4] triazole-6-one scaffold. A series of 24 novel …

Thiazolidin-4-one-based derivatives–Efficient tools for designing antiprotozoal agents. A review of the last decade

H Tuszewska, J Szczepański, S Mandziuk… - Bioorganic Chemistry, 2023 - Elsevier
Thiazolidin-4-one derivatives have a wide range of therapeutic implementations and clinical
significance for medicinal chemistry. This heterocyclic ring has been reported to possess a …

[HTML][HTML] Evaluation of anticonvulsant activity of dual COX-2/5-LOX inhibitor darbufelon and its novel analogues

M Mishchenko, S Shtrygol', A Lozynskyi… - Scientia …, 2021 - mdpi.com
Neuroinflammation is an integral part of epilepsy pathogenesis and other convulsive
conditions, and non-steroidal anti-inflammatory drugs (NSAIDs) present a potent tool for the …