Pathogenesis of celiac disease and other gluten related disorders in wheat and strategies for mitigating them
Wheat is a major cereal crop providing energy and nutrients to the billions of people around
the world. Gluten is a structural protein in wheat, that is necessary for its dough making …
the world. Gluten is a structural protein in wheat, that is necessary for its dough making …
CRISPR/Cas9 gene editing of gluten in wheat to reduce gluten content and exposure—Reviewing methods to screen for coeliac safety
A Jouanin, LJWJ Gilissen, JG Schaart, FJ Leigh… - Frontiers in …, 2020 - frontiersin.org
Ingestion of gluten proteins (gliadins and glutenins) from wheat, barley and rye can cause
coeliac disease (CD) in genetically predisposed individuals. The only remedy is a strict and …
coeliac disease (CD) in genetically predisposed individuals. The only remedy is a strict and …
[HTML][HTML] Biochemical characteristics and potential applications of ancient cereals-An underexploited opportunity for sustainable production and consumption
G Zamaratskaia, K Gerhardt, K Wendin - Trends in Food Science & …, 2021 - Elsevier
Background There is currently renewed interest in foods based on ancient cereals because
consumers often consider such foods to be healthy and sustainable. Interest in ancient …
consumers often consider such foods to be healthy and sustainable. Interest in ancient …
Impact and mechanism of sulphur-deficiency on modern wheat farming nitrogen-related sustainability and gliadin content
Two challenges that the global wheat industry is facing are a lowering nitrogen-use
efficiency (NUE) and an increase in the reporting of wheat-protein related health issues …
efficiency (NUE) and an increase in the reporting of wheat-protein related health issues …
[HTML][HTML] Improving wheat to remove coeliac epitopes but retain functionality
PR Shewry, AS Tatham - Journal of Cereal Science, 2016 - Elsevier
Coeliac disease is an intolerance triggered by the ingestion of wheat gluten proteins. It is of
increasing concern to consumers and health professionals as its incidence appears to be …
increasing concern to consumers and health professionals as its incidence appears to be …
Outlook for coeliac disease patients: towards bread wheat with hypoimmunogenic gluten by gene editing of α-and γ-gliadin gene families
Background Wheat grains contain gluten proteins, which harbour immunogenic epitopes
that trigger Coeliac disease in 1–2% of the human population. Wheat varieties or accessions …
that trigger Coeliac disease in 1–2% of the human population. Wheat varieties or accessions …
[HTML][HTML] A curated gluten protein sequence database to support development of proteomics methods for determination of gluten in gluten-free foods
The unique physiochemical properties of wheat gluten enable a diverse range of food
products to be manufactured. However, gluten triggers coeliac disease, a condition which is …
products to be manufactured. However, gluten triggers coeliac disease, a condition which is …
Targeting of prolamins by RNA i in bread wheat: effectiveness of seven silencing‐fragment combinations for obtaining lines devoid of coeliac disease epitopes from …
Gluten proteins are responsible for the viscoelastic properties of wheat flour but also for
triggering pathologies in susceptible individuals, of which coeliac disease (CD) and …
triggering pathologies in susceptible individuals, of which coeliac disease (CD) and …
New traits in crops produced by genome editing techniques based on deletions
CCM Van de Wiel, JG Schaart, LAP Lotz… - Plant biotechnology …, 2017 - Springer
One of the most promising New Plant Breeding Techniques is genome editing (also called
gene editing) with the help of a programmable site-directed nuclease (SDN). In this review …
gene editing) with the help of a programmable site-directed nuclease (SDN). In this review …
[HTML][HTML] Genome-wide analysis of complex wheat gliadins, the dominant carriers of celiac disease epitopes
DW Wang, D Li, J Wang, Y Zhao, Z Wang, G Yue… - Scientific reports, 2017 - nature.com
Gliadins, specified by six compound chromosomal loci (Gli-A1/B1/D1 and Gli-A2/B2/D2) in
hexaploid bread wheat, are the dominant carriers of celiac disease (CD) epitopes. Because …
hexaploid bread wheat, are the dominant carriers of celiac disease (CD) epitopes. Because …