A dual pharmacological strategy against COVID-19: The therapeutic potential of metformin and atorvastatin

LA De Jesús-González, RM Del Ángel… - Microorganisms, 2024 - mdpi.com
Metformin (MET) and atorvastatin (ATO) are promising treatments for COVID-19. This review
explores the potential of MET and ATO, commonly prescribed for diabetes and dyslipidemia …

An ivermectin–atorvastatin combination impairs nuclear transport inhibiting dengue infection in vitro and in vivo

SN Palacios-Rápalo, CN Farfan-Morales… - Iscience, 2023 - cell.com
Dengue virus (DENV) uses cellular nuclear transport machinery to import some proteins into
the nucleus. Recently, the non-structural protein 3 (NS3) of DENV was localized in the …

Pin-pointing the key hubs in the IFN-γ pathway responding to SARS-CoV-2 infection

A Toro, S Lage-Vickers, J Bizzotto, F Vilicich, A Sabater… - Viruses, 2022 - mdpi.com
Interferon gamma (IFN-γ) may be potential adjuvant immunotherapy for COVID-19 patients.
In this work, we assessed gene expression profiles associated with the IFN-γ pathway in …

Antiviral activity of repurposing ivermectin against a panel of 30 clinical SARS-CoV-2 strains belonging to 14 variants

O Delandre, M Gendrot, P Jardot, M Le Bideau… - Pharmaceuticals, 2022 - mdpi.com
Over the past two years, several variants of SARS-CoV-2 have emerged and spread all over
the world. However, infectivity, clinical severity, re-infection, virulence, transmissibility …

Antiparasitic drugs against SARS-CoV-2: a comprehensive literature survey

E Calvo-Alvarez, M Dolci, F Perego, L Signorini… - Microorganisms, 2022 - mdpi.com
More than two years have passed since the viral outbreak that led to the novel infectious
respiratory disease COVID-19, caused by the SARS-CoV-2 coronavirus. Since then, the …

Potential role of PIM1 inhibition in the treatment of SARS-CoV-2 infection

MMF Ismail, RR El-Awady, AM Farrag… - Journal of Genetic …, 2023 - Springer
Background SARS-CoV-2 infection involves disturbing multiple molecular pathways related
to immunity and cellular functions. PIM1 is a serine/threonine-protein kinase found to be …

[HTML][HTML] Safety and efficacy of a MEURI program for the use of high dose ivermectin in COVID-19 patients

MA Mayer, A Krolewiecki, MR Kohan - Frontiers in Public Health, 2022 - frontiersin.org
Background In the absence of antiviral alternatives, interventions under research for COVID-
19 might be offered following guidelines from WHO for monitored emergency use of …

[HTML][HTML] 1-L Transcription in Prion Diseases

J Nahalka - International Journal of Molecular Sciences, 2024 - mdpi.com
Understanding the pathogenesis and mechanisms of prion diseases can significantly
expand our knowledge in the field of neurodegenerative diseases. Prion biology is …

[PDF][PDF] Pin-Pointing the Key Hubs in the IFN-γ Pathway Responding to SARS-CoV-2 Infection. Viruses 2022, 14, 2180

A Toro, S Lage-Vickers, J Bizzotto, F Vilicich, A Sabater… - 2022 - researchgate.net
Interferon gamma (IFN-γ) may be potential adjuvant immunotherapy for COVID-19 patients.
In this work, we assessed gene expression profiles associated with the IFN-γ pathway in …

[PDF][PDF] Study of ATPase and GTPase levels in Fibrotic Lung Disease with and without COVID-19 Vaccination

RM Al-Azawee, ZM Al-Rubaei - Journal of the Faculty of Medicine Baghdad, 2024 - iasj.net
Background: In eukaryotic cells, the acidification of intracellular compartments is the
responsibility of vacuolar H+ ATPase, a family of proton pumps, sometimes known as V …