Ischemic insults on neurons trigger excessive, pathological glutamate release that causes
Ca 2+ overload resulting in neuronal cell death (excitotoxicity). The Ca 2+/calmodulin (CaM) …

This review presents the accumulating evidence for the roles of protein phosphatase 6 (PP6)
in cell cycle, DNA damage repair, inflammatory signaling, lymphocyte development, virus …

Extracellular mitogen signal transduction is initiated by ligand binding to specific receptors of
target cells. This causes a cellular response that frequently triggers the activation of tyrosine …

Introduction: Cell division cycle progression is achieved by a sequential and stringently
concerted activation of a family of serine–threonine kinases, namely the cyclin-dependent …

Epidemiological data clearly establishes cigarette smoking as one of the major cause for
lung cancer worldwide. Recently, targeted therapy has become one of the most preferred …

Summary p27Kip1, a cyclin-dependent kinase (CDK) inhibitor, is a multi-functional protein
that regulates various cellular activities. Trophoblast proliferation, migration and invasion are …

Abstract CIP/KIP and INK4 families of Cyclin-dependent kinase inhibitors (CKIs) are well-
established cell cycle regulatory proteins whose canonical function is binding to Cyclin-CDK …

Chemoresistance is one of the leading causes that contributes to tumor relapse and poor
patient outcome after several rounds of drug therapy. The causes of chemoresistance are …

The cyclin-dependent kinase (CDK) inhibitor p27 has an important role in cell cycle
regulation. Reduced expression of p27 is commonly associated with poor prognosis in many …

Crosslinking BCR in the immature B cell line WEHI-231 causes apoptosis. We found that Bcl-
xL was degraded by polyubiquitination upon BCR crosslinking and in this study explored the …