Functions of the neocortex depend on its bidirectional communication with the thalamus, via
cortico-thalamo-cortical (CTC) loops. Recent work dissecting the synaptic connectivity in …

Biological neuronal networks are highly adaptive and plastic. For instance, spike-timing-
dependent plasticity (STDP) is a core mechanism which adapts the synaptic strengths based …

Spike-timing-dependent plasticity (STDP) is one of the important rules for the change of
synaptic weights between neurons in biological nervous systems. In this paper, we study the …

The thalamus receives input from 3 distinct cortical layers, but input from only 2 of these has
been well characterized. We therefore investigated whether the third input, derived from …

The canonical cortical microcircuit has principally been defined by interlaminar excitatory
connections among the six layers of the neocortex. However, excitatory neurons in layer 6 …

Spiking neural networks (SNNs), which are composed of biologically plausible spiking
neurons, and combined with bio-physically realistic auditory periphery models, offer a …

Layer 6 (L6) is the sole purveyor of corticothalamic (CT) feedback to first-order thalamus and
also sends projections to higher-order thalamus, yet how it engages the full corticothalamic …

The synaptic organization of the brain is constantly modified by activity-dependent synaptic
plasticity. In several neurological disorders, abnormal neuronal activity and pathological …

En route from the retina to the cortex, visual information passes through the dorsolateral
geniculate nucleus (dLGN) of the thalamus, where extensive corticothalamic (CT) feedback …

Cortical networks are characterized by the origin, destination, and reciprocity of their
connections, as well as by the diameter, conduction velocity, and synaptic efficacy of their …