Excitotoxicity in ALS: overstimulation, or overreaction?

AE King, A Woodhouse, MTK Kirkcaldie… - Experimental neurology, 2016 - Elsevier
Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease that results
in motor dysfunction and death, generally from respiratory failure. 90% of ALS cases are …

Cytokine and growth factor activation in vivo and in vitro after spinal cord injury

E Garcia, J Aguilar-Cevallos… - Mediators of …, 2016 - Wiley Online Library
Spinal cord injury results in a life‐disrupting series of deleterious interconnected
mechanisms encompassed by the primary and secondary injury. These events are mediated …

[PDF][PDF] Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons

BJ Wainger, E Kiskinis, C Mellin, O Wiskow, SSW Han… - Cell reports, 2014 - cell.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor
nervous system. We show using multielectrode array and patch-clamp recordings that …

[HTML][HTML] Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS

K Weskamp, EM Tank, R Miguez… - The Journal of …, 2020 - Am Soc Clin Investig
Cortical hyperexcitability and mislocalization of the RNA-binding protein TDP43 are highly
conserved features in amyotrophic lateral sclerosis (ALS). Nevertheless, the relationship …

[HTML][HTML] Spinal cord trauma and the molecular point of no return

PK Yip, A Malaspina - Molecular neurodegeneration, 2012 - Springer
A mechanical trauma to the spinal cord can be followed by the development of irreversible
and progressive neurodegeneration, as opposed to a temporary or partially reversible …

Astrocytic K+ clearance during disease progression in amyotrophic lateral sclerosis

R Stevenson, E Samokhina, A Mangat, I Rossetti… - Glia, 2023 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder in which patients lose
motor functions due to progressive loss of motor neurons in the cortex, brainstem, and spinal …

Ion channels in neurological disorders

P Kumar, D Kumar, SK Jha, NK Jha… - Advances in protein …, 2016 - Elsevier
The convergent endeavors of the neuroscientist to establish a link between clinical
neurology, genetics, loss of function of an important protein, and channelopathies behind …

Motor cortical function determines prognosis in sporadic ALS

K Shibuya, SB Park, N Geevasinga, P Menon… - Neurology, 2016 - AAN Enterprises
Objective: To study the relationship between cortical function and survival in amyotrophic
lateral sclerosis (ALS). Methods: A total of 216 referrals were screened, and participants with …

Motoneuron excitability dysfunction in ALS: Pseudo‐mystery or authentic conundrum?

SM Elbasiouny - The Journal of physiology, 2022 - Wiley Online Library
In amyotrophic lateral sclerosis (ALS), abnormalities in motoneuronal excitability are seen in
early pathogenesis and throughout disease progression. Fully understanding motoneuron …

Impairments in motor neurons, interneurons and astrocytes contribute to hyperexcitability in ALS: underlying mechanisms and paths to therapy

D Do-Ha, Y Buskila, L Ooi - Molecular neurobiology, 2018 - Springer
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by
the loss of motor neurons leading to progressive paralysis and death. Using transcranial …