Biogenic phytochemicals modulating obesity: From molecular mechanism to preventive and therapeutic approaches

V Kumar, DD Singh, SS Lakhawat… - Evidence‐Based …, 2022 - Wiley Online Library
The incidence of obesity and over bodyweight is emerging as a major health concern.
Obesity is a complex metabolic disease with multiple pathophysiological clinical conditions …

Cornelian Cherry (Cornus mas L.) Fruit Extract Lowers SREBP-1c and C/EBPα in Liver and Alters Various PPAR-α, PPAR-γ, LXR-α Target Genes in Cholesterol-Rich …

M Danielewski, A Rapak, A Kruszyńska… - International Journal of …, 2024 - mdpi.com
Cornelian cherry (Cornus mas L.) fruits, abundant in iridoids and anthocyanins, are natural
products with proven beneficial impacts on the functions of the cardiovascular system and …

Molecular dynamics articulated multilevel virtual screening protocol to discover novel dual PPAR α/γ agonists for anti-diabetic and metabolic applications

S Mandal, S Faizan, NM Raghavendra, BRP Kumar - Molecular Diversity, 2023 - Springer
PPARα and PPARγ are isoforms of the nuclear receptor superfamily which regulate glucose
and lipid metabolism. Activation of PPARα and PPARγ receptors by exogenous ligands …

Ursolic acid regulates key EMT transcription factors, induces cell cycle arrest and apoptosis in MDA‐MB‐231 and MCF‐7 breast cancer cells, an in‐vitro and in silico …

V Mallepogu, KR Sankaran, C Pasala… - Journal of Cellular …, 2023 - Wiley Online Library
Epithelial–mesenchymal transition (EMT) is a vital process in tumorigenesis and metastasis
of breast cancer. In our quest to explore effective anticancer alternatives, ursolic acid (UA) …

Thymoquinone mitigates obesity and diabetic parameters through regulation of major adipokines, key lipid metabolizing enzymes and AMPK/p-AMPK in diet-induced …

K Ramineedu, KR Sankaran, V Mallepogu… - 3 Biotech, 2024 - Springer
The present study was designed to evaluate the anti-obesity and anti-hyperglycemic activity
of Thymoquinone (ThyQ) isolated from Nigella sativa seeds. Male Wistar rats were randomly …

Mulberry extract ameliorates T2DM-related symptoms via AMPK pathway in STZ-HFD-induced C57BL/6J mice

L Zhang, X Zhou, H Chen, L You, T Zhang… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Mulberry (Morus alba L.) is not only a tasty food
but also a beneficial medicinal substance that has been historically used to treat diabetes …

[HTML][HTML] Astragalin and rutin restore gut microbiota dysbiosis, alleviate obesity and insulin resistance in high-fat diet-fed C57BL/6J mice

MS Ganjayi, KR Sankaran, B Meriga, R Bhatia… - Food Science and …, 2024 - Elsevier
In the present study we investigated the impact of the combination of astragalin and rutin
(CAR) on restoring gut-microbial dysbiosis and obesity and obesity related disorders …

达乌尔黄鼠季节性肥胖与胰腺功能稳态.

刘继鸿, 刘新宇, 侯婷婷, 杨明… - Chinese Journal of …, 2024 - search.ebscohost.com
摘要储脂类冬眠动物在入眠前的育肥阶段大量积累体脂作为越冬的重要能源物质. 达乌尔黄鼠(
Spermophilus dauricus) 在短短2~ 3 个月的育肥期间体质量增加近1 倍, 然而该物种快速育肥 …

[HTML][HTML] Anti-Adipogenic and Anti-Obesity Effects of Gongmi Tea and Gongmi So Extract

SJ Jo, Y Gong, R Jiang, H Jung… - Preventive Nutrition and …, 2023 - ncbi.nlm.nih.gov
The prevalence of obesity has been increasing worldwide, and its pathogenesis is closely
related to preadipo-cyte differentiation. Because the presence of obesity increases the risk of …

Role of Ethnomedicinal Resources to Cure Metabolic Diseases

S Bhattacharjee, A Banerjee - Traditional Resources and Tools for Modern …, 2024 - Springer
The rising incidences and prevalence of metabolic diseases, creating enormous health and
economic burden worldwide, are a global healthcare challenge. Such conditions, which can …