Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …

Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation
and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to …

Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate
environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment …

The high metabolic demand of cancer cells leads to an accumulation of H+ ions in the
tumour microenvironment. The disorganized tumour vasculature prevents an efficient wash …

In response to skeletal muscle contraction during exercise, paracrine factors coordinate
tissue remodeling, which underlies this healthy adaptation. Here we describe a pH-sensing …

Measurement of oxygen consumption is a powerful and uniquely informative experimental
technique. It can help identify mitochondrial mechanisms of action following pharmacologic …

Partitioning of ATP generation between glycolysis and oxidative phosphorylation is central
to cellular bioenergetics but cumbersome to measure. We describe here how rates of ATP …

Neurons require mechanisms to maintain ATP homeostasis in axons, which are highly
vulnerable to bioenergetic failure. Here, we elucidate a transcellular signaling mechanism …

Mitochondria are well appreciated for their role as biosynthetic and bioenergetic organelles.
In the past two decades, mitochondria have emerged as signaling organelles that contribute …

Biological energy transduction underlies all physiological phenomena in cells. The
metabolic systems that support energy transduction have been of great interest due to their …