The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …

The eukaryotic RNA polymerase II (RNAPII) catalyzes the transcription of all protein
encoding genes and is also responsible for the generation of small regulatory RNAs. RNAPII …

Transport of messenger RNA (mRNA) from the nucleus to the cytoplasm is an essential step
of eukaryotic gene expression. In the cell nucleus, a precursor mRNA undergoes a series of …

Transcription in the nucleus of animal cells is performed by three distinct RNA polymerases
(RNAP), namely RNAPI, RNAPII, and RNAPIII. Among them, RNAPII is responsible for the …

Abstract Background Peptidyl-prolyl isomerases (PPIases) are enzymes that assist in the
folding of newly-synthesized proteins and regulate the stability, localization, and activity of …

To facilitate selfish replication, viruses halt host gene expression in various ways. The
nuclear export of mRNA is one such process targeted by many viruses. SARS-CoV-2, the …

African swine fever virus (ASFV), a large, enveloped, icosahedral dsDNA virus, is currently
the only known DNA-containing arbovirus and the only recognized member of the family …

Members of the Polycomb group of repressors and trithorax group of activators maintain
heritable states of transcription by modifying nucleosomal histones or remodeling chromatin …

Stressed cells coordinate a multi‐faceted response spanning many levels of physiology. Yet
knowledge of the complete stress‐activated regulatory network as well as design principles …

During transcription initiation, the TFIIH-kinase Kin28/Cdk7 marks RNA polymerase II (Pol II)
by phosphorylating the C-terminal domain (CTD) of its largest subunit. Here we describe a …