The role of reactive oxygen species in arsenic toxicity

Y Hu, J Li, B Lou, R Wu, G Wang, C Lu, H Wang, J Pi… - Biomolecules, 2020 - mdpi.com
Arsenic poisoning is a global health problem. Chronic exposure to arsenic has been
associated with the development of a wide range of diseases and health problems in …

Chronic kidney disease and exposure to nephrotoxic metals

SE Orr, CC Bridges - International journal of molecular sciences, 2017 - mdpi.com
Chronic kidney disease (CKD) is a common progressive disease that is typically
characterized by the permanent loss of functional nephrons. As injured nephrons become …

Antioxidant enzymes regulation in plants in reference to reactive oxygen species (ROS) and reactive nitrogen species (RNS)

D Kapoor, S Singh, V Kumar, R Romero, R Prasad… - Plant gene, 2019 - Elsevier
Reactive oxygen species (ROS) are generated in the plants during cellular metabolism. But
extreme environmental conditions like drought, salinity or floods etc. lead to an enhanced …

Zingerone reduces sodium arsenite-induced nephrotoxicity by regulating oxidative stress, inflammation, apoptosis and histopathological changes

N Akaras, C Gur, S Kucukler, FM Kandemir - Chemico-biological …, 2023 - Elsevier
Arsenic is widely available in the environment and arsenic toxicity is a public health problem
of serious concern worldwide. Zingerone is a promising phytochemical with various …

Regulation of Sirt1/Nrf2/TNF-α signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity

D Yang, X Tan, Z Lv, B Liu, R Baiyun, J Lu, Z Zhang - Scientific Reports, 2016 - nature.com
Inorganic mercury, though a key component of pediatric vaccines, is an environmental
toxicant threatening human health via accumulating oxidative stress in part. Luteolin has …

Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress

JA Martina, R Puertollano - Journal of Biological Chemistry, 2018 - ASBMB
Adaptations and responses to stress conditions are fundamental processes that all cells
must accomplish to maintain or restore cellular homeostasis. Cells have a plethora of …

Salvianolic acid A attenuates arsenic-induced ferroptosis and kidney injury via HIF-2α/DUOX1/GPX4 and iron homeostasis

D Yang, X Xia, S Xi - Science of The Total Environment, 2024 - Elsevier
Arsenic (As) is a prevalent pollutant in the environment and causes a high frequency of
kidney disease in areas of high arsenic contamination, but its pathogenic mechanisms have …

Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells

K Jiang, W Wang, X Jin, Z Wang, Z Ji… - Oncology …, 2015 - spandidos-publications.com
Silibinin, derived from the milk thistle plant (Silybum marianum), has anticancer and
chemopreventive properties. Silibinin has been reported to inhibit the growth of various …

Copper (II) and/or arsenite-induced oxidative stress cascades apoptosis and autophagy in the skeletal muscles of chicken

Y Wang, H Zhao, Y Shao, J Liu, J Li, L Luo, M Xing - Chemosphere, 2018 - Elsevier
Arsenic (As) is a ubiquitous environmental toxin and robust inducer of oxidative stress (OxS).
Copper (Cu) is an essential microelement, which participates in OxS as a cofactor for certain …

Targeting reactive oxygen species in cancer via Chinese herbal medicine

Q Qian, W Chen, Y Cao, Q Cao, Y Cui… - … Medicine and Cellular …, 2019 - Wiley Online Library
Recently, reactive oxygen species (ROS), a class of highly bioactive molecules, have been
extensively studied in cancers. Cancer cells typically exhibit higher levels of basal ROS than …