Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …

After more than two decades of preclinical and clinical studies, on August 27, 2019, the US
Food and Drug Administration (FDA) approved the adenosine A 2A receptor antagonist …

The notion of “immune privilege” of the brain has been revised to accommodate its
infiltration, at steady state, by immune cells that participate in normal neurophysiology …

Neuroinflammation in patients with Alzheimer's disease (AD) and related mouse models has
been recognized for decades, but the contribution of the recently described meningeal …

Synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies, are
neurodegenerative disorders that are characterized by the accumulation of α-synuclein …

Synaptic dysfunction plays a central role in Alzheimer's disease (AD), since it drives the
cognitive decline. An association between a polymorphism of the adenosine A2A receptor …

Adenosine receptor subtypes, first described 40 years ago, are known to regulate diverse
biological functions and have a role in various conditions, such as cerebral and cardiac …

Cordyceps sinensis, also called DongChongXiaCao (winter worm, summer grass) in
Chinese, is becoming increasingly popular and important in the public and scientific …

Worldwide, the incidence of major depressive disorder (MDD) is increasing annually,
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …

Recent studies combining pharmacological, behavioral, electrophysiological and molecular
approaches indicate that depression results from maladaptive neuroplastic processes …