Galectin-3 (Gal-3) regulates basic cellular functions such as cell–cell and cell–matrix
interactions, growth, proliferation, differentiation, and inflammation. It is not surprising …

Defensins are a major family of host defense peptides expressed predominantly in
neutrophils and epithelial cells. Their broad antimicrobial activities and multifaceted …

The therapeutic targeting of extracellular proteins is becoming hugely attractive in light of
evidence implicating the tumour microenvironment as pivotal in all aspects of tumour …

Abstract Renal Cell Carcinoma (RCC) has the highest mortality rate of the genitourinary
cancers and the incidence of RCC has risen steadily. If detected early, RCC is curable by …

The invariant chain (CD74) is well known for its essential role in antigen presentation by
mediating assembly and subcellular trafficking of the MHCII complex. Beyond this, CD74 …

Just two and a half decades ago adult renal cell neoplasms, ie, those arising from the renal
tubules or collecting duct epithelium, were subdivided into two major subtypes:“clear cell …

CONTEXT: The natural history of renal cell carcinoma (RCC) is highly unpredictable. Small
renal masses may be accompanied by metastatic disease. Conversely, patients with locally …

Exposure to arsenic (As) is a global public health problem because of its association with
various cancers and numerous other pathological effects, and millions of people worldwide …

The histological assessment of human tissue has emerged as the key challenge for
detection and treatment of cancer. A plethora of different data sources ranging from tissue …

We identified previously an up-regulation in lysyl oxidase (LOX) expression, an extracellular
matrix remodeling enzyme, in a highly invasive/metastatic human breast cancer cell line …