Chitin metabolism in insects: structure, function and regulation of chitin synthases and chitinases

H Merzendorfer, L Zimoch - Journal of Experimental Biology, 2003 - journals.biologists.com
Chitin is one of the most important biopolymers in nature. It is mainly produced by fungi,
arthropods and nematodes. In insects, it functions as scaffold material, supporting the …

Recent advances in understanding mechanisms of insect cuticle differentiation

B Moussian - Insect biochemistry and molecular biology, 2010 - Elsevier
Insects possess a cuticle that covers all tissues exposed to the outside world including the
body, the fore-and hindgut and the luminal side of the tracheae. The cuticle is a …

Insect chitin synthases: a review

H Merzendorfer - Journal of Comparative Physiology B, 2006 - Springer
Chitin is the most widespread amino polysaccharide in nature. The annual global amount of
chitin is believed to be only one order of magnitude less than that of cellulose. It is a linear …

Population bulk segregant mapping uncovers resistance mutations and the mode of action of a chitin synthesis inhibitor in arthropods

T Van Leeuwen, P Demaeght… - Proceedings of the …, 2012 - National Acad Sciences
Because of its importance to the arthropod exoskeleton, chitin biogenesis is an attractive
target for pest control. This point is demonstrated by the economically important benzoylurea …

Chitin synthesis inhibitors: old molecules and new developments

H Merzendorfer - Insect science, 2013 - Wiley Online Library
Chitin is the most abundant natural aminopolysaccharide and serves as a structural
component of extracellular matrices. It is found in fungal septa, spores, and cell walls, and in …

The Tribolium chitin synthase genes TcCHS1 and TcCHS2 are specialized for synthesis of epidermal cuticle and midgut peritrophic matrix

Y Arakane, S Muthukrishnan, KJ Kramer… - Insect molecular …, 2005 - Wiley Online Library
Functional analysis of the two chitin synthase genes, TcCHS1 and TcCHS2, in the red flour
beetle, Tribolium castaneum, revealed unique and complementary roles for each gene …

serpentine and vermiform encode matrix proteins with chitin binding and deacetylation domains that limit tracheal tube length in Drosophila

S Luschnig, T Bätz, K Armbruster, MA Krasnow - Current Biology, 2006 - cell.com
Many organs contain epithelial tubes that transport gases or liquids [1]. Proper tube size and
shape is crucial for organ function, but the mechanisms controlling tube diameter and length …

A Homolog of Drosophila grainy head Is Essential for Epidermal Integrity in Mice

SB Ting, J Caddy, N Hislop, T Wilanowski, A Auden… - Science, 2005 - science.org
The Drosophila cuticle is essential for maintaining the surface barrier defenses of the fly.
Integral to cuticle resilience is the transcription factor grainy head, which regulates …

RNAi-induced phenotypes suggest a novel role for a chemosensory protein CSP5 in the development of embryonic integument in the honeybee (Apis mellifera)

J Maleszka, S Forêt, R Saint, R Maleszka - Development genes and …, 2007 - Springer
Small chemosensory proteins (CSPs) belong to a conserved, but poorly understood, protein
family found in insects and other arthropods. They exhibit both broad and restricted …

Embryonic desiccation resistance in Aedes aegypti: presumptive role of the chitinized Serosal Cuticle

GL Rezende, AJ Martins, C Gentile, LC Farnesi… - BMC developmental …, 2008 - Springer
Background One of the major problems concerning dengue transmission is that embryos of
its main vector, the mosquito Aedes aegypti, resist desiccation, surviving several months …