Codon usage bias, the preference for certain synonymous codons, is found in all genomes.
Although synonymous mutations were previously thought to be silent, a large body of …

Ribosome profiling, which involves the deep sequencing of ribosome-protected mRNA
fragments, is a powerful tool for globally monitoring translation in vivo. The method has …

Cancer cells selectively promote translation of specific oncogenic transcripts to facilitate
cancer survival and progression, but the underlying mechanisms are poorly understood …

Pancreatic ductal adenocarcinoma (PDAC) tumors have a nutrient-poor, desmoplastic, and
highly innervated tumor microenvironment. Although neurons can release stimulatory factors …

The translation of messenger RNA (mRNA) into protein and the folding of the resulting
protein into an active form are prerequisites for virtually every cellular process and represent …

Ribosome rescue pathways recycle stalled ribosomes and target problematic mRNAs and
aborted proteins for degradation,. In bacteria, it remains unclear how rescue pathways …

No-go decay (NGD) is a eukaryotic quality control mechanism that evolved to cope with
translational arrests. The process is characterized by an endonucleolytic cleavage near the …

The eukaryotic translation factor eIF5A, originally identified as an initiation factor, was later
shown to promote translation elongation of iterated proline sequences. Using a combination …

Bacteria growing under different conditions experience a broad range of demand on the rate
of protein synthesis, which profoundly affects cellular resource allocation. During fast growth …

In eukaryotes, ribosome profiling provides insight into the mechanism of protein synthesis at
the codon level. In bacteria, however, the method has been more problematic and no …